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Unfortunately, the antibody LS-C209309 is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



TNFRSF10B / Killer / DR5 Antibodies

tumor necrosis factor receptor superfamily, member 10b

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB.

Gene Name: tumor necrosis factor receptor superfamily, member 10b
Family/Subfamily: TNF Receptor , not assigned-TNF Receptor
Synonyms: TNFRSF10B Antibody, Cytotoxic TRAIL receptor-2 Antibody, CD262 antigen Antibody, DR5 Antibody, Death receptor 5 Antibody, KILLER Antibody, TRAIL-R2 Antibody, TRICK2B Antibody, TRAILR2 Antibody, TRICK2A Antibody, TRICKB Antibody, TRICK2 Antibody, CD262 Antibody, Fas-like protein Antibody, TRAIL receptor 2 Antibody, ZTNFR9 Antibody
Target Sequences: NM_147187 Q6FH58 O14763
 TNFRSF10B / Killer / DR5 Feature Table
Featured Image

Featured TNFRSF10B / Killer / DR5 Antibody

LS-B2074 is a rabbit polyclonal antibody that LifeSpan has tested extensively in immunohistochemistry (IHC) and is an excellent antibody for use in formalin-fixed paraffin embedded tissues. Multiple tissues were immunolabeled and the results were interpreted by a LifeSpan pathologist. This image shows an example of staining in formalin-fixed paraffin embedded tissue. Learn more about our IHC Validation procedure. All LSBio antibodies are 100% guaranteed.

Publications (2)

1
Bortezomib and depsipeptide sensitize tumors to tumor necrosis factor-related apoptosis-inducing ligand: a novel method to potentiate natural killer cell tumor cytotoxicity. Lundqvist A, Abrams SI, Schrump DS, Alvarez G, Suffredini D, Berg M, Childs R. Cancer research. 2006 66:7317-25. [PubMed:16849582] Related Antibodies: LS-C40991.
2
Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma. Shi J, Tricot GJ, Garg TK, Malaviarachchi PA, Szmania SM, Kellum RE, Storrie B, Mulder A, Shaughnessy JD, Barlogie B, van Rhee F. Blood. 2008 111:1309-17. [PubMed:17947507] [PMC:PMC2214736] Related Antibodies: LS-C40990.

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Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
TNFRSF10B / Killer / DR5 Rabbit IgG Polyclonal Unconjugated Human IHC-P, ICC, WB, Flo aa388-407 No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (aa388-407) IHC-plus™ LS-B2074
IHC Image
WB Image
Rabbit Polyclonal (IgG) to Human TNFRSF10B / Killer / DR5
Human
IHC - Paraffin, ICC, Western blot, Flow Cytometry
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit Polyclonal Unconjugated Human, Mouse IHC-P, ICC, IF, WB C-Terminus No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (C-Terminus) IHC-plus™ LS-B136
IHC Image
IF Image
Rabbit Polyclonal to Human TNFRSF10B / Killer / DR5
Human, Mouse
IHC - Paraffin, ICC, Immunofluorescence, Western blot
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit IgG Polyclonal Unconjugated Human IHC-P, WB aa380-398 No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (aa380-398) IHC-plus™ LS-B5086
IHC Image
IHC Image
Rabbit Polyclonal (IgG) to Human TNFRSF10B / Killer / DR5
Human
IHC - Paraffin, Western blot
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit Polyclonal Unconjugated Human IHC-P, WB, Flo No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody IHC-plus™ LS-B8498
IHC Image
Rabbit Polyclonal
Human
IHC - Paraffin, Western blot, Flow Cytometry
Unconjugated
TNFRSF10B / Killer / DR5 Mouse IgG1 Monoclonal 1B9 Unconjugated Human IHC-P, WB aa203-411 No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (aa203-411, clone 1B9) LS-C340229
IHC Image
IHC Image
Mouse Monoclonal [clone 1B9] (IgG1) to Human TNFRSF10B / Killer / DR5
Human
IHC - Paraffin, Western blot
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit IgG Polyclonal Unconjugated Human IHC-P, WB aa333-348 No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (aa333-348) LS-C312985
IHC Image
WB Image
Rabbit Polyclonal (IgG) to Human TNFRSF10B / Killer / DR5
Human
IHC - Paraffin, Western blot
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit IgG Polyclonal Unconjugated Human IHC, WB No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody LS-C335142
IHC Image
Rabbit Polyclonal (IgG) to Human TNFRSF10B / Killer / DR5
Human
IHC, Western blot
Unconjugated
TNFRSF10B / Killer / DR5 Goat Polyclonal Unconjugated Human IHC, WB, Flo, ELISA Extracellular Domain No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (Extracellular Domain) LS-C83941
IHC Image
Goat Polyclonal to Human TNFRSF10B / Killer / DR5
Human
IHC, Western blot, Flow Cytometry, ELISA
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, WB, ELISA Internal No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (Internal) LS-C137118
WB Image
Rabbit Polyclonal (IgG) to Human TNFRSF10B / Killer / DR5
Human, Mouse, Rat
IHC, Western blot, ELISA
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit Polyclonal Unconjugated Human IHC, WB No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody LS-C192498
WB Image
Rabbit Polyclonal to Human TNFRSF10B / Killer / DR5
Human
IHC, Western blot
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit Polyclonal Unconjugated, Azide-free Human IHC-P, WB, Flo aa417-436 No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (aa417-436, Azide-free) LS-C148093
Rabbit Polyclonal to Human TNFRSF10B / Killer / DR5
Human
IHC - Paraffin, Western blot, Flow Cytometry
Unconjugated, Azide-free
TNFRSF10B / Killer / DR5 Rabbit IgG Polyclonal Unconjugated Human IHC, WB, ELISA No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody LS-C188972
Rabbit Polyclonal (IgG) to Human TNFRSF10B / Killer / DR5
Human
IHC, Western blot, ELISA
Unconjugated
TNFRSF10B / Killer / DR5 Hamster IgG Monoclonal MD5-1 PE Conjugated Mouse Flo No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (clone MD5-1, PE) LS-C106773
Flo Image
Flo Image
Hamster Monoclonal [clone MD5-1] (IgG) to Mouse TNFRSF10B / Killer / DR5
Mouse
Flow Cytometry
PE Conjugated
TNFRSF10B / Killer / DR5 Hamster IgG Monoclonal MD5-1 Unconjugated Mouse Flo No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (clone MD5-1) LS-C106618
Flo Image
Flo Image
Hamster Monoclonal [clone MD5-1] (IgG) to Mouse TNFRSF10B / Killer / DR5
Mouse
Flow Cytometry
Unconjugated
TNFRSF10B / Killer / DR5 Hamster IgG Monoclonal MD5-1 Biotin Conjugated Mouse Flo No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (clone MD5-1, Biotin) LS-C106170
Flo Image
Flo Image
Hamster Monoclonal [clone MD5-1] (IgG) to Mouse TNFRSF10B / Killer / DR5
Mouse
Flow Cytometry
Biotin Conjugated
TNFRSF10B / Killer / DR5 Rabbit IgG Polyclonal Unconjugated Mouse WB, ELISA aa233-367 No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (aa233-367) LS-C296880
WB Image
Rabbit Polyclonal (IgG) to Mouse TNFRSF10B / Killer / DR5
Mouse
Western blot, ELISA
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit IgG Polyclonal Unconjugated Mouse WB, ELISA aa54-180 No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (aa54-180) LS-C296875
WB Image
Rabbit Polyclonal (IgG) to Mouse TNFRSF10B / Killer / DR5
Mouse
Western blot, ELISA
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit IgG Polyclonal Unconjugated Human WB, ELISA aa234-435 No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (aa234-435) LS-C314631
WB Image
Rabbit Polyclonal (IgG) to Human TNFRSF10B / Killer / DR5
Human
Western blot, ELISA
Unconjugated
TNFRSF10B / Killer / DR5 Mouse IgG1 Monoclonal DJR2-2 (2-6) Unconjugated Human Flo Extracellular Domain Yes Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (Extracellular Domain, clone DJR2-2 (2-6)) LS-C40990
PublicationsPublications (1)
Flo Image
Mouse Monoclonal [clone DJR2-2 (2-6)] (IgG1) to Human TNFRSF10B / Killer / DR5
Human
Flow Cytometry
Unconjugated
TNFRSF10B / Killer / DR5 Mouse IgG1 Monoclonal DJR2-4 (7-8) Unconjugated Human Flo Extracellular Domain Yes Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (Extracellular Domain, clone DJR2-4 (7-8)) LS-C40991
PublicationsPublications (1)
Flo Image
Mouse Monoclonal [clone DJR2-4 (7-8)] (IgG1) to Human TNFRSF10B / Killer / DR5
Human
Flow Cytometry
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit Polyclonal Unconjugated Mouse, Human WB No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody LS-C48171
WB Image
Rabbit Polyclonal to Mouse TNFRSF10B / Killer / DR5
Mouse, Human
Western blot
Unconjugated
TNFRSF10B / Killer / DR5 Mouse IgG1,k Monoclonal DJR2-4 (a.k.a. 7-8) Unconjugated Human Flo No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (clone DJR2-4 (a.k.a. 7-8)) LS-C107120
Flo Image
Mouse Monoclonal [clone DJR2-4 (a.k.a. 7-8)] (IgG1,k) to Human TNFRSF10B / Killer / DR5
Human
Flow Cytometry
Unconjugated
TNFRSF10B / Killer / DR5 Mouse IgG1,k Monoclonal DJR2-4 (a.k.a. 7-8) PE Conjugated Human Flo No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (clone DJR2-4 (a.k.a. 7-8), PE) LS-C106080
Flo Image
Mouse Monoclonal [clone DJR2-4 (a.k.a. 7-8)] (IgG1,k) to Human TNFRSF10B / Killer / DR5
Human
Flow Cytometry
PE Conjugated
TNFRSF10B / Killer / DR5 Rabbit IgG Polyclonal Unconjugated Human WB aa38-87 No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (aa38-87) LS-C82022
WB Image
Rabbit Polyclonal (IgG) to Human TNFRSF10B / Killer / DR5
Human
Western blot
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit IgG Polyclonal Unconjugated Human WB, ELISA N-Terminus No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (N-Terminus) LS-C40706
Rabbit Polyclonal (IgG) to Human TNFRSF10B / Killer / DR5
Human
Western blot, ELISA
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit IgG Polyclonal Unconjugated Human WB, ELISA aa280-296 No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (aa280-296) LS-C40740
Rabbit Polyclonal (IgG) to Human TNFRSF10B / Killer / DR5
Human
Western blot, ELISA
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit IgG Polyclonal Unconjugated Human WB, ELISA Internal No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (Internal) LS-C136985
Rabbit Polyclonal (IgG) to Human TNFRSF10B / Killer / DR5
Human
Western blot, ELISA
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit IgG Polyclonal Biotin Conjugated Mouse WB, ELISA aa54-180 No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (aa54-180, Biotin) LS-C300149
Rabbit Polyclonal (IgG) to Mouse TNFRSF10B / Killer / DR5
Mouse
Western blot, ELISA
Biotin Conjugated
TNFRSF10B / Killer / DR5 Rabbit IgG Polyclonal Biotin Conjugated Mouse WB, ELISA aa233-367 No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (aa233-367, Biotin) LS-C300287
Rabbit Polyclonal (IgG) to Mouse TNFRSF10B / Killer / DR5
Mouse
Western blot, ELISA
Biotin Conjugated
TNFRSF10B / Killer / DR5 Mouse Monoclonal Unconjugated Human, Mouse ICC, WB No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody LS-C342028
Mouse Monoclonal to Human TNFRSF10B / Killer / DR5
Human, Mouse
ICC, Western blot
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit Polyclonal Unconjugated Human, Mouse, Rat WB No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody LS-C340936
Rabbit Polyclonal to Human TNFRSF10B / Killer / DR5
Human, Mouse, Rat
Western blot
Unconjugated
TNFRSF10B / Killer / DR5 Mouse IgG1 Monoclonal DR5-01-1 PE Conjugated Human Flo Extracellular Domain No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (Extracellular Domain, clone DR5-01-1, PE) LS-C46528
Mouse Monoclonal [clone DR5-01-1] (IgG1) to Human TNFRSF10B / Killer / DR5
Human
Flow Cytometry
PE Conjugated
TNFRSF10B / Killer / DR5 Mouse IgG1 Monoclonal DR5-01-1 FITC Conjugated Human Flo Extracellular Domain No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (Extracellular Domain, clone DR5-01-1, FITC) LS-C46417
Mouse Monoclonal [clone DR5-01-1] (IgG1) to Human TNFRSF10B / Killer / DR5
Human
Flow Cytometry
FITC Conjugated
TNFRSF10B / Killer / DR5 Mouse IgG1 Monoclonal DR5-01 Unconjugated Human Flo Extracellular Domain No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (Extracellular Domain, clone DR5-01) LS-C204183
Mouse Monoclonal [clone DR5-01] (IgG1) to Human TNFRSF10B / Killer / DR5
Human
Flow Cytometry
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit IgG Polyclonal FITC Conjugated Mouse WB aa54-180 No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (aa54-180, FITC) LS-C304763
Rabbit Polyclonal (IgG) to Mouse TNFRSF10B / Killer / DR5
Mouse
Western blot
FITC Conjugated
TNFRSF10B / Killer / DR5 Rabbit IgG Polyclonal FITC Conjugated Mouse WB aa233-367 No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (aa233-367, FITC) LS-C304696
Rabbit Polyclonal (IgG) to Mouse TNFRSF10B / Killer / DR5
Mouse
Western blot
FITC Conjugated
TNFRSF10B / Killer / DR5 Rabbit Polyclonal Unconjugated Human WB No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody LS-C82978
Rabbit Polyclonal to Human TNFRSF10B / Killer / DR5
Human
Western blot
Unconjugated
TNFRSF10B / Killer / DR5 Mouse IgG1,k Monoclonal DJR2-2 (a.k.a. 2-6) Unconjugated Human Flo No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (clone DJR2-2 (a.k.a. 2-6)) LS-C107027
Mouse Monoclonal [clone DJR2-2 (a.k.a. 2-6)] (IgG1,k) to Human TNFRSF10B / Killer / DR5
Human
Flow Cytometry
Unconjugated
TNFRSF10B / Killer / DR5 Mouse IgG1,k Monoclonal DJR2-4 (a.k.a. 7-8) Biotin Conjugated Human Flo No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (clone DJR2-4 (a.k.a. 7-8), Biotin) LS-C106955
Mouse Monoclonal [clone DJR2-4 (a.k.a. 7-8)] (IgG1,k) to Human TNFRSF10B / Killer / DR5
Human
Flow Cytometry
Biotin Conjugated
TNFRSF10B / Killer / DR5 Mouse IgG1 Monoclonal DR5-01-1 Unconjugated Human Flo Extracellular Domain No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (Extracellular Domain, clone DR5-01-1) LS-C46124
Mouse Monoclonal [clone DR5-01-1] (IgG1) to Human TNFRSF10B / Killer / DR5
Human
Flow Cytometry
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit Polyclonal Unconjugated Human WB aa388-407 No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (aa388-407) LS-C83377
Rabbit Polyclonal to Human TNFRSF10B / Killer / DR5
Human
Western blot
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit Polyclonal Unconjugated Human WB No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody LS-C82979
Rabbit Polyclonal to Human TNFRSF10B / Killer / DR5
Human
Western blot
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit IgG Polyclonal Unconjugated Human N-Terminus No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (N-Terminus) LS-C195972
Rabbit Polyclonal (IgG) to Human TNFRSF10B / Killer / DR5
Human
Unconjugated
TNFRSF10B / Killer / DR5 Mouse IgG1,k Monoclonal Unconjugated Human WB, IP, ELISA aa71-170 No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (aa71-170) LS-C307889
Mouse Monoclonal (IgG1,k) to Human TNFRSF10B / Killer / DR5
Human
Western blot, Immunoprecipitation, ELISA
Unconjugated
TNFRSF10B / Killer / DR5 Rat IgG2a Monoclonal Unconjugated Mouse IP, Flo aa1-170 No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (aa1-170) LS-C36145
Rat Monoclonal (IgG2a) to Mouse TNFRSF10B / Killer / DR5
Mouse
Immunoprecipitation, Flow Cytometry
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit IgG Polyclonal Unconjugated Human WB, ELISA N-Terminus No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (N-Terminus) LS-C39772
Rabbit Polyclonal (IgG) to Human TNFRSF10B / Killer / DR5
Human
Western blot, ELISA
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit Polyclonal Unconjugated Human WB, Flo No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody LS-C14922
Rabbit Polyclonal to Human TNFRSF10B / Killer / DR5
Human
Western blot, Flow Cytometry
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit IgG Polyclonal Unconjugated Human WB, IP No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody LS-C310174
Rabbit Polyclonal (IgG) to Human TNFRSF10B / Killer / DR5
Human
Western blot, Immunoprecipitation
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit IgG Polyclonal Unconjugated Human ICC, WB C-Terminus No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (C-Terminus) LS-C188971
Rabbit Polyclonal (IgG) to Human TNFRSF10B / Killer / DR5
Human
ICC, Western blot
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit IgG Polyclonal Unconjugated Human WB No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody LS-C310176
Rabbit Polyclonal (IgG) to Human TNFRSF10B / Killer / DR5
Human
Western blot
Unconjugated
TNFRSF10B / Killer / DR5 Mouse IgG Polyclonal Unconjugated Human WB No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody LS-C307891
Mouse Polyclonal (IgG) to Human TNFRSF10B / Killer / DR5
Human
Western blot
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit IgG Polyclonal Unconjugated Human WB aa388-407 No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (aa388-407) LS-C65016
Rabbit Polyclonal (IgG) to Human TNFRSF10B / Killer / DR5
Human
Western blot
Unconjugated
TNFRSF10B / Killer / DR5 Rabbit IgG Polyclonal Unconjugated Human WB aa380-398 No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (aa380-398) LS-C39848
Rabbit Polyclonal (IgG) to Human TNFRSF10B / Killer / DR5
Human
Western blot
Unconjugated
TNFRSF10B / Killer / DR5 Mouse IgG2a Monoclonal TS106 Unconjugated Human WB aa56-128 No Primary
Anti-TNFRSF10B / Killer / DR5 Antibody (aa56-128, clone TS106) LS-C191499
Mouse Monoclonal [clone TS106] (IgG2a) to Human TNFRSF10B / Killer / DR5
Human
Western blot
Unconjugated
Target Corresponding Antibodies
TNFRSF10B / Killer / DR5
TNFRSF10B / Killer / DR5 Antibody Blocking Peptide - LS-E10618
LS-E10618
TNFRSF10B / Killer / DR5
LS-C82022
TNFRSF10B / Killer / DR5
TNFRSF10B / Killer / DR5 Antibody Blocking Peptide - LS-E29870
LS-E29870
TNFRSF10B / Killer / DR5
LS-B136
Type Target Reactivity Sample Type
Sandwich TNFRSF10B / Killer / DR5 Human Cell Culture Supernatants, Plasma, Serum
Human TNFRSF10B / Killer / DR5 ELISA Kit - LS-F200
Sandwich
Human
96-Well Microplate with Colorimetric - 450nm detection type
Cell Culture Supernatants, Plasma, Serum

TNFRSF10B / Killer / DR5 Feature Table


Feature Type Location Details
alternative products 1 - 440 Event=Alternative splicing; Named isoforms=3; Name=Long; Synonyms=TRICK2B; IsoId=O14763-1; Sequence=Displayed; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; Name=3; IsoId=O14763-3; Sequence=VSP_039125; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; Name=Short; Synonyms=TRICK2A; IsoId=O14763-2; Sequence=VSP_006490; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay;
Disease 1 - 440 Defects in TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known as squamous cell carcinoma of the head and neck.
Function 1 - 440 Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B.
Induction 1 - 440 TNFRSF10B is regulated by the tumor suppressor p53.
interaction 1 - 440 Q96P48:ARAP1; NbExp=1; IntAct=EBI-518882, EBI-710003;
Similarity 1 - 440 Contains 1 death domain.
Similarity 1 - 440 Contains 3 TNFR-Cys repeats.
Subcellular Location 1 - 440 Membrane; Single-pass type I membrane protein.
Subunit 1 - 440 Homotrimer. Can interact with TRADD and RIP.
Tissue Specificity 1 - 440 Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLa S3, K562, HL-60, SW480, A549 and G361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.
arrayexpress 1 - 440 O14763
bgee 1 - 440 O14763
cleanex 1 - 440 HS_TNFRSF10B
ctd 1 - 440 8795
dip 1 - 440 DIP-33566N
doi 1 - 440 10
eggnog 1 - 440 maNOG21635
embl 1 - 440 AB014718
embl 1 - 440 AC107959
embl 1 - 440 AF012535
embl 1 - 440 AF012628
embl 1 - 440 AF016266
embl 1 - 440 AF016268
embl 1 - 440 AF016849
embl 1 - 440 AF018657
embl 1 - 440 AF018658
embl 1 - 440 AF020501
embl 1 - 440 AF022386
embl 1 - 440 AF153687
embl 1 - 440 AF192548
embl 1 - 440 AY358277
embl 1 - 440 BC001281
embl 1 - 440 BX538104
ensembl 1 - 440 ENST00000276431
ensembl 1 - 440 ENST00000347739
gene3d 1 - 440 G3DSA:1.10.533.10
genecards 1 - 440 GC08M022933
geneid 1 - 440 8795
genevestigator 1 - 440 O14763
germonline 1 - 440 ENSG00000120889
go 1 - 440 GO:0004872
go 1 - 440 GO:0005886
go 1 - 440 GO:0006919
go 1 - 440 GO:0007166
go 1 - 440 GO:0007250
go 1 - 440 GO:0008625
go 1 - 440 GO:0008633
go 1 - 440 GO:0008656
go 1 - 440 GO:0016021
go 1 - 440 GO:0043123
go 1 - 440 GO:0045569
hgnc 1 - 440 HGNC:11905
hovergen 1 - 440 HBG061626
hpa 1 - 440 HPA023625
inparanoid 1 - 440 O14763
intact 1 - 440 O14763
interpro 1 - 440 IPR000488
interpro 1 - 440 IPR001368
interpro 1 - 440 IPR011029
interpro 1 - 440 IPR020465
ipi 1 - 440 IPI00296379
ipi 1 - 440 IPI00296380
ipi 1 - 440 IPI00965817
kegg 1 - 440 hsa:8795
medline 1 - 440 20017054
medline 1 - 440 21060022
medline 1 - 440 22887296
medline 1 - 440 97390508
medline 1 - 440 97390509
medline 1 - 440 97431692
medline 1 - 440 97459925
medline 1 - 440 97467318
medline 1 - 440 97467719
medline 1 - 440 98039016
medline 1 - 440 98090092
mim 1 - 440 275355
mim 1 - 440 603612
mint 1 - 440 MINT-109111
nextbio 1 - 440 32984
orphanet 1 - 440 67037
pathway_interaction_db 1 - 440 trail_pathway
pdb 1 - 440 1D0G
pdb 1 - 440 1D4V
pdb 1 - 440 1DU3
pdb 1 - 440 1ZA3
pdb 1 - 440 2H9G
pdbsum 1 - 440 1D0G
pdbsum 1 - 440 1D4V
pdbsum 1 - 440 1DU3
pdbsum 1 - 440 1ZA3
pdbsum 1 - 440 2H9G
pfam 1 - 440 PF00020
pfam 1 - 440 PF00531
pharmgkb 1 - 440 PA36598
pirsf 1 - 440 PIRSF037867
pride 1 - 440 O14763
prints 1 - 440 PR01956
prosite 1 - 440 PS00652
prosite 1 - 440 PS50017
prosite 1 - 440 PS50050
proteinmodelportal 1 - 440 O14763
pubmed 1 - 440 10072170
pubmed 1 - 440 10542098
pubmed 1 - 440 10549288
pubmed 1 - 440 12975309
pubmed 1 - 440 14759258
pubmed 1 - 440 15489334
pubmed 1 - 440 16421571
pubmed 1 - 440 17974005
pubmed 1 - 440 9242610
pubmed 1 - 440 9242611
pubmed 1 - 440 9285725
pubmed 1 - 440 9311998
pubmed 1 - 440 9325248
pubmed 1 - 440 9326928
pubmed 1 - 440 9373179
pubmed 1 - 440 9430227
reactome 1 - 440 REACT_578
refseq 1 - 440 NP_003833.4
refseq 1 - 440 NP_671716.2
smart 1 - 440 SM00005
smart 1 - 440 SM00208
smr 1 - 440 O14763
string 1 - 440 O14763
supfam 1 - 440 SSF47986
ucsc 1 - 440 uc003xct.1
ucsc 1 - 440 uc003xcu.1
unigene 1 - 440 Hs.521456
not_annotated_cds; genomic_dna 1 - 440 -
chain 56 - 440 Tumor necrosis factor receptor superfamily member 10B. /FTId=PRO_0000034580.
compbias 250 - 253 Poly-Gly
conflict 439 - 439 M -> L (in Ref. 8; AAB67103 and 12; AAQ88644).
domain 339 - 422 Death
repeat 57 - 94 TNFR-Cys 1
repeat 97 - 137 TNFR-Cys 2
repeat 138 - 178 TNFR-Cys 3
repeat 192 - 206 TAPE
topo_dom 56 - 210 Extracellular (Potential)
topo_dom 232 - 440 Cytoplasmic (Potential)
transmem 211 - 231 Helical; (Potential)
var_seq 119 - 440 Missing (in isoform 3) /FTId=VSP_039125.
var_seq 185 - 213 Missing (in isoform Short) /FTId=VSP_006490.
variant 32 - 32 P -> L (in dbSNP:rs1129424) /FTId=VAR_016153.
variant 67 - 67 A -> V (in dbSNP:rs1047266) /FTId=VAR_016154.
variant 191 - 191 A -> V (in dbSNP:rs13265018) /FTId=VAR_059831.
keyword 1 - 440 3D-structure
keyword 1 - 440 Alternative splicing
keyword 1 - 440 Apoptosis
keyword 1 - 440 Complete proteome
keyword 1 - 440 Direct protein sequencing
keyword 1 - 440 Disulfide bond
keyword 1 - 440 Membrane
keyword 1 - 440 Polymorphism
keyword 1 - 440 Receptor
keyword 1 - 440 Repeat
keyword 1 - 440 Signal
keyword 1 - 440 Transmembrane
keyword 1 - 440 Transmembrane helix
Molecular Weight 1 - 440 47850
1 hit 1 - 440 PF00020
1 hit 1 - 440 PF00531
1 hit 1 - 440 PS50017
2 hits 1 - 440 PS00652
2 hits 1 - 440 PS50050

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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