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Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
Gene Name: | tumor necrosis factor, alpha-induced protein 8 |
Synonyms: | TNFAIP8, GG2-1, MDC-3.13, NDED, TNF alpha-induced protein 8, TNF-induced protein GG2-1, SCCS2, SCC-S2 |
Target Sequences: | NM_014350 NP_055165.2 O95379 |
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