TNFAIP3 / A20

tumor necrosis factor, alpha-induced protein 3

Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of proinflammatory cytokines and IFN beta in LPS-tolerized macrophages.

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

TNFAIP3 / A20 (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human TNFAIP3 / A20 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67222

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

89.4 kDa

Price:

20 µg/$1,107

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Human TNFAIP3 / A20 Protein (Recombinant GST, N-terminus) (aa691-790) - LS-G60386

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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TNFAIP3 / A20 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115412

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

90.1 kDa

Price:

100 µg/$710

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Human TNFAIP3 / A20 Protein (Recombinant GST) (Full Length) - LS-G30736

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

55.3 kDa

Price:

2 µg/$439

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Human TNFAIP3 / A20 Protein (Recombinant His-T7) (aa1-300) - LS-G25105

Source:

E. coli

Tag:

His-T7

Molecular Weight:

38.9 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human TNFAIP3 / A20 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79363

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

90.1 kDa

Price:

20 µg/$215

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