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TMPRSS2 / Epitheliasin
transmembrane protease, serine 2
Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) , human coronavirus EMC (HCoV-EMC), SARS-CoV and SARS-CoV-2, and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.
| Gene Name: | transmembrane protease, serine 2 |
| Family/Subfamily: | Protease , Serine S1 |
| Synonyms: | TMPRSS2, Epitheliasin, PRSS10, Serine protease 10, PP9284, host protease for SARS-CoV-2 replication |
| Target Sequences: | NM_005656 NP_005647.3 O15393 |
Publications (4)
1
Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity10<sup> Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Member of Fraunhofer International Consortium for Anti-Infective Research (iCAIR), Nikolai-Fuchs-Strasse 1, 30625 Hannover, Germany12<sup> Discovery Technology Rese. Markus Hoffmann, Heike Hofmann-Winkler, Joan C Smith, Nadine Krüger, Prerna Arora, Lambert K Sørensen, Ole S Søgaard, Jørgen Bo Hasselstrøm, Michael Winkler, Tim Hempel, Lluís Raich, Simon Olsson, Olga Danov, Danny Jonigk, Takashi Yamazoe, Katsura Yamatsuta, Hirotaka Mizuno, Stephan Ludwig, Frank Noé, Mads Kjolby, Armin Braun, Jason M Sheltzer, Stefan Pöhlmann. EBioMedicine. 2021 Mar;;65:103255. [Full Text Article]
[PubMed:33676899]
[PMC:PMC7930809]
2
Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry. bioRxiv : the preprint server for biology. 2021 Jul; [Full Text Article]
[PubMed:33821268]
[PMC:PMC8020968]
3
Synergistic inhibition of SARS-CoV-2 cell entry by otamixaban and covalent protease inhibitors: pre-clinical assessment of pharmacological and molecular properties. Tim Hempel , Katarina Elez, Nadine Krüger, Lluís Raich, Jonathan H Shrimp, Olga Danov, Danny Jonigk , Armin Braun, Min Shen, Matthew D Hall, Stefan Pöhlmann , Markus Hoffmann , Frank Noé. Chemical science. 2021 Aug;12:12600-12609. [Full Text Article]
[PubMed:34703545]
[PMC:PMC8494051]
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(37)
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(37)
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TMPRSS2 / Epitheliasin
(37)
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Human
(27)
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(17)
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(6)
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(3)
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(3)
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(6)
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(34)
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rabbit
(35)
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(34)
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(35)
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(5)
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(6)
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(36)
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(2)
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(2)
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(4)
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(2)
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(2)
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(4)
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(4)
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(2)
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(17)
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aa254-490
(8)
aa284-492
(8)
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(4)
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(4)
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(1)
aa100-470
(1)
aa314-343
(1)
Publications
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(36)
Yes
(1)
TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal (aa314-343) Antibody
Human
Flo, WB
Unconjugated
400 µl/$393
TMPRSS2 / Epitheliasin Rabbit anti-Mouse Polyclonal (aa254-490) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
TMPRSS2 / Epitheliasin Rabbit anti-Mouse Polyclonal (aa254-490) (HRP) Antibody
Mouse
WB
HRP Conjugated
100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722; 2 ml/$959; 5 ml/$1,639
TMPRSS2 / Epitheliasin Rabbit anti-Mouse Polyclonal (aa254-490) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387
TMPRSS2 / Epitheliasin Rabbit anti-Mouse Polyclonal (aa254-490) (FITC) Antibody
Mouse
WB
FITC Conjugated
100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765
TMPRSS2 / Epitheliasin Rabbit anti-Mouse Polyclonal (aa254-490) (PE) Antibody
Mouse
WB
PE Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
TMPRSS2 / Epitheliasin Rabbit anti-Mouse Polyclonal (aa254-490) (APC) Antibody
Mouse
WB
APC Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
TMPRSS2 / Epitheliasin Rabbit anti-Mouse Polyclonal (aa254-490) (APC, Cy7) Antibody
Mouse
WB
APC, Cy7 Conjugated
100 µl/$513; 200 µl/$666; 500 µl/$1,175; 1 ml/$1,441; 2 ml/$2,017; 5 ml/$3,781
TMPRSS2 / Epitheliasin Rabbit anti-Mouse Polyclonal (aa254-490) (Cy3) Antibody
Mouse
WB
Cy3 Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
TMPRSS2 / Epitheliasin Mouse anti-Human Monoclonal (2F4) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal (aa100-470) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
TMPRSS2 / Epitheliasin Goat anti-Human Polyclonal (Internal Region) Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal (aa284-492) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal (aa284-492) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$338; 200 µl/$393; 500 µl/$575; 1 ml/$702; 2 ml/$939; 5 ml/$1,593
TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
Fast Shipping
TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$440
Fast Shipping
TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$440
TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Rabbit, Mouse, Bovine, Rat, Pig, Human
WB
FITC Conjugated
100 µl/$469
TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
TMPRSS2 / Epitheliasin Rabbit anti-Human Polyclonal Antibody
Human
IHC-P
Unconjugated
20 µl/$271; 100 µl/$412
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product results
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