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TLR9

toll-like receptor 9

TLR9 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.

Gene Name: toll-like receptor 9
Family/Subfamily: Toll-like Receptor , not assigned-Toll-like Receptor
Synonyms: TLR9, CD289, CD289 antigen, Scri2a, Toll-like receptor 9
Target Sequences: NM_017442 NP_059138.1 Q9NR96

Publications (1)

1
Association of self-DNA mediated TLR9-related gene, DNA methyltransferase, and cytokeratin protein expression alterations in HT29-cells to DNA fragment length and methylation status. Fűri I, Sipos F, Spisák S, Kiszner G, Wichmann B, Schöller A, Tulassay Z, Műzes G, Molnár B. TheScientificWorldJournal. 2014 2013:293296. (WB; Human) [Full Text Article] [PubMed:24459426] [PMC:PMC3891537] Related Antibodies: LS-B2341.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).