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TLR2

toll-like receptor 2

Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.

Gene Name:	toll-like receptor 2
Family/Subfamily:	Toll-like Receptor , not assigned-Toll-like Receptor
Synonyms:	TLR2, CD282 antigen, CD282, TIL4, Toll-like receptor 2
Target Sequences:	NM_003264 NP_003255.2 O60603

Publications (12)

High-mobility group box 1 activates integrin-dependent homing of endothelial progenitor cells. Chavakis E, Hain A, Vinci M, Carmona G, Bianchi ME, Vajkoczy P, Zeiher AM, Chavakis T, Dimmeler S. Circulation research. 2007 100:204-12. [PubMed:17218606] Related Antibodies: LS-C40823.

Bacterial peptidoglycan breaks down intestinal tolerance via mast cell activation: the role of TLR2 and NOD2. Wu L, Feng BS, He SH, Zheng PY, Croitoru K, Yang PC. Immunology and cell biology. 2007 85:538-45. [PubMed:17563761] Related Antibodies: LS-C98266.

Vibrio vulnificus IlpA-induced cytokine production is mediated by Toll-like receptor 2. Goo SY, Han YS, Kim WH, Lee KH, Park SJ. The Journal of biological chemistry. 2007 282:27647-58. [PubMed:17640874] Related Antibodies: LS-C40823.

Bovine monocyte TLR2 receptors differentially regulate the intracellular fate of Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium. Weiss DJ, Souza CD, Evanson OA, Sanders M, Rutherford M. Journal of leukocyte biology. 2008 83:48-55. [PubMed:17913973] Related Antibodies: LS-C40823.

Monocytes differentiated with GM-CSF and IL-15 initiate Th17 and Th1 responses that are contact-dependent and mediated by IL-15. Harris KM. Journal of leukocyte biology. 2011 90:727-34. [PubMed:21724805] Related Antibodies: LS-C40823.

Structural determination and Toll-like receptor 2-dependent proinflammatory activity of dimycolyl-diarabino-glycerol from Mycobacterium marinum. Elass-Rochard E, Rombouts Y, Coddeville B, Maes E, Blervaque R, Hot D, Kremer L, Gurardel Y. The Journal of biological chemistry. 2012 287:34432-44. [PubMed:22798072] [PMC:PMC3464548] Related Antibodies: LS-C40823.

Activation of MyD88-dependent TLR1/2 signaling by misfolded a-synuclein, a protein linked to neurodegenerative disorders. Daniele SG, Béraud D, Davenport C, Cheng K, Yin H, Maguire-Zeiss KA. Science signaling. 2015 8:ra45. (WB; Mouse) [Full Text Article] [PubMed:25969543] [PMC:PMC4601639] Related Antibodies: LS-C98268.

A comparison of the impact of Shimen and C strains of classical swine fever virus on Toll-like receptor expression. Cao Z, Guo K, Zheng M, Ning P, Li H, Kang K, Lin Z, Zhang C, Liang W, Zhang Y. The Journal of general virology. 2015 96:1732-45. (WB; Human) [Full Text Article] [PubMed:25805409] Related Antibodies: LS-C116906.

Tissue expression of Toll-like receptors 2, 3, 4 and 7 in swine in response to the Shimen strain of classical swine fever virus. Cao Z, Zheng M, Lv H, Guo K, Zhang Y. Molecular medicine reports. 2018 May;17:7122-7130. (Rabbit, Mouse) [Full Text Article] [PubMed:29568891] [PMC:PMC5928672] Related Antibodies: LS-C116906.

VB-201, an oxidized phospholipid small molecule, inhibits CD14- and Toll-like receptor-2-dependent innate cell activation and constrains atherosclerosis. Mendel I, Feige E, Yacov N, Salem Y, Levi I, Propheta-Meiran O, Shoham A, Ishai E, George J, Harats D, Breitbart E. Clinical and experimental immunology. 2014 January;175:126-37. [Full Text Article] [PubMed:24116867] [PMC:PMC3898561] Related Antibodies: LS-C10673.

Correlation between innate and adaptive immunity response in TB children post BCG vaccination. Is it effective or not?: Cross-sectional study. Rahmini Shabariah, Farsida, Mochammad Hatta, Ilhamjaya Patellongi, Irfan Idris, Arif Santoso, Andi Asadul Islam, Rosdiana Natzir, Bob Wahyudin, Warsinggih, Sanjoyo. Annals of medicine and surgery (2012). 2022 May;77:103586. [Full Text Article] [PubMed:35638072] [PMC:PMC9142374]

Comparison TLR2 and TLR4 serum levels in children with pulmonary and extrapulmonary tuberculosis with and without a Bacillus Calmette-Guérin (BCG) scar. Rahmini Shabariah, Mochammad Hatta, Irfan Idris, Arif Santoso, Ilhamjaya Patellongi, Tria Astika Endah Permatasari, Farsida, Andi Asadul Islam, Rosdiana Natzir, Bob Wahyudin, Warsinggih, Emilda. Journal of clinical tuberculosis and other mycobacterial diseases. 2021 December;25:100272. [Full Text Article] [PubMed:34504953] [PMC:PMC8416952]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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