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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TLR2

toll-like receptor 2

Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.

Gene Name: toll-like receptor 2
Family/Subfamily: Toll-like Receptor , not assigned-Toll-like Receptor
Synonyms: TLR2, CD282 antigen, CD282, TIL4, Toll-like receptor 2
Target Sequences: NM_003264 NP_003255.2 O60603

Publications (8)

1
High-mobility group box 1 activates integrin-dependent homing of endothelial progenitor cells. Chavakis E, Hain A, Vinci M, Carmona G, Bianchi ME, Vajkoczy P, Zeiher AM, Chavakis T, Dimmeler S. Circulation research. 2007 100:204-12. [PubMed:17218606] Related Antibodies: LS-C40823.
2
Bacterial peptidoglycan breaks down intestinal tolerance via mast cell activation: the role of TLR2 and NOD2. Wu L, Feng BS, He SH, Zheng PY, Croitoru K, Yang PC. Immunology and cell biology. 2007 85:538-45. [PubMed:17563761] Related Antibodies: LS-C98266.
3
Vibrio vulnificus IlpA-induced cytokine production is mediated by Toll-like receptor 2. Goo SY, Han YS, Kim WH, Lee KH, Park SJ. The Journal of biological chemistry. 2007 282:27647-58. [PubMed:17640874] Related Antibodies: LS-C40823.
4
Bovine monocyte TLR2 receptors differentially regulate the intracellular fate of Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium. Weiss DJ, Souza CD, Evanson OA, Sanders M, Rutherford M. Journal of leukocyte biology. 2008 83:48-55. [PubMed:17913973] Related Antibodies: LS-C40823.
5
Monocytes differentiated with GM-CSF and IL-15 initiate Th17 and Th1 responses that are contact-dependent and mediated by IL-15. Harris KM. Journal of leukocyte biology. 2011 90:727-34. [PubMed:21724805] Related Antibodies: LS-C40823.
6
Structural determination and Toll-like receptor 2-dependent proinflammatory activity of dimycolyl-diarabino-glycerol from Mycobacterium marinum. Elass-Rochard E, Rombouts Y, Coddeville B, Maes E, Blervaque R, Hot D, Kremer L, Gurardel Y. The Journal of biological chemistry. 2012 287:34432-44. [PubMed:22798072] [PMC:PMC3464548] Related Antibodies: LS-C40823.
7
Activation of MyD88-dependent TLR1/2 signaling by misfolded a-synuclein, a protein linked to neurodegenerative disorders. Daniele SG, Béraud D, Davenport C, Cheng K, Yin H, Maguire-Zeiss KA. Science signaling. 2015 8:ra45. (WB; Mouse) [Full Text Article] [PubMed:25969543] [PMC:PMC4601639] Related Antibodies: LS-C98268.
8
A comparison of the impact of Shimen and C strains of classical swine fever virus on Toll-like receptor expression. Cao Z, Guo K, Zheng M, Ning P, Li H, Kang K, Lin Z, Zhang C, Liang W, Zhang Y. The Journal of general virology. 2015 96:1732-45. (WB; Human) [Full Text Article] [PubMed:25805409] Related Antibodies: LS-C116906.
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Filtered By: None
Target
TLR2 (280)
Reactivity
Human (225)
Mouse (86)
Rat (17)
Bovine (5)
Canine (1)
Chimpanzee (6)
Crab-eating macaque (1)
Cynomolgus (2)
Cynomolgus monkey (1)
Dog (22)
Gibbon (3)
Goat (4)
Horse (4)
Marmoset (1)
Monkey (21)
Orangutan (3)
Pig (4)
Rabbit (5)
Rhesus monkey (2)
Sheep (4)
Application
IHC (130)
IHC-Fr (48)
IHC-P (34)
WB (157)
Flo (145)
Block (1)
ELISA (51)
Func (19)
ICC (15)
IF (32)
IP (76)
Neut (2)
RIA (1)
Host
rabbit (103)
mouse (161)
goat (3)
chicken (1)
rat (12)
Isotype
IgG (108)
IgG1 (29)
IgG1,k (6)
IgG2a (86)
IgG2a,k (17)
IgG2b (13)
Clonality
monoclonal mc (173)
polyclonal pc (107)
Clone
1070CT4.2.3.2 (1)
11G7 (5)
13A73 (2)
2B4A1 (6)
2G9 (1)
67N17F8 (1)
67N8F8 (2)
6C2 (5)
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ABM3A87 (1)
GF1 (1)
IMG11G5 (2)
m T2.4 (1)
mT2.7 (12)
MT2.7 (2)
T2.5 (2)
TL2.1 (20)
TL2.3 (8)
TL2.3, Biotinylated (1)
TLR2.45 (3)
TLR2/221 (2)
Format
AP Conjugated (8)
APC (6)
APC Conjugated (13)
Azide-free (13)
Biotin Conjugated (43)
CF Conjugated (1)
Cy3 Conjugated (6)
Cy7 Conjugated (6)
FITC Conjugated (43)
HRP Conjugated (17)
Low Endotoxin (4)
PE Conjugated (26)
RPE Conjugated (8)
Unconjugated (109)
Epitope
aa47-245 (26)
aa25-250 (10)
aa595-760 (10)
aa212-242 (8)
aa281-310 (8)
aa644-784 (8)
aa720-749 (8)
N-Terminus (4)
aa180-229 (4)
aa591-640 (4)
aa180-196 (3)
aa227-398 (2)
aa400-450 (2)
C-Terminus (1)
Extracellular Domain (1)
N-Terminal (1)
aa180-420 (1)
aa221-384 (1)
aa227-397 (1)
aa364-379 (1)
aa564-580 (1)
Publications
No (276)
Yes (4)
Showing 1-25 of 280 results

TLR2 Antibody (N-Terminus) IHC-plus™ LS-B1417
Rabbit Polyclonal (IgG) to Human TLR2
Mouse, Human
ELISA IF IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-TLR2 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2 ug/ml.
Immunofluorescence of TLR2 in Human Spleen cells with TLR2 antibody at 10 ug/ml.
Anti-TLR2 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2 ug/ml.
Immunofluorescence of TLR2 in Human Spleen cells with TLR2 antibody at 10 ug/ml.

TLR2 Antibody (aa720-749) LS-C98268
Publications (1)
Publications (1)
Rabbit Polyclonal to Mouse TLR2
Mouse
IHC IHC-P WB
Unconjugated
400µl  $305.00
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with Mouse Tlr2 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with Mouse Tlr2 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

TLR2 Antibody (aa212-242) LS-C98266
Publications (1)
Publications (1)
Rabbit Polyclonal to Human TLR2
Human
Flo IHC IHC-P WB
Unconjugated
400µl  $305.00
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with TLR2 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Western blot of hTLR2-C226 in K562 cell line lysates (35 ug/lane). TLR2 (arrow) was detected using the purified antibody.
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with TLR2 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Western blot of hTLR2-C226 in K562 cell line lysates (35 ug/lane). TLR2 (arrow) was detected using the purified antibody.

TLR2 Antibody LS-C10673
Mouse Monoclonal (IgG2a) to Human TLR2
Human, Monkey
Flo IHC IHC-Fr IHC-P IP Neut WB
Unconjugated
100µg 0.1mg/ml  $710.00

TLR2 Antibody (Biotin) LS-C10664
Mouse Monoclonal (IgG2a) to Human TLR2
Human
Flo
Biotin Conjugated
100µg 0.5mg/ml  $485.00

TLR2 Antibody (clone TL2.1) LS-C40823
Publications (5)
Publications (5)
Mouse Monoclonal [clone TL2.1] (IgG2a) to Human TLR2
Human
Flo IHC IP WB
Unconjugated
100µg 0.5mg/ml  $305.00
Human peripheral blood monocytes stained with TL2.1 FITC.
Human peripheral blood monocytes stained with TL2.1 FITC.

TLR2 Antibody (aa591-640) LS-C116906
Publications (1)
Publications (1)
Rabbit Polyclonal to Human TLR2
Rabbit, Mouse, Goat, Sheep, Bovine, Pig, Horse, Human
WB
Unconjugated
50µg  $365.00
TLR2 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
TLR2 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

TLR2 Antibody (clone TL2.1, Azide-free) LS-C148160
Mouse Monoclonal [clone TL2.1] (IgG2a) to Human TLR2
Dog, Human
Flo IP Neut
Unconjugated, Azide-free
100µg 0.5mg/ml  $335.00

TLR2 Antibody (aa180-420, clone ABM3A87) IHC-plus™ LS-B13487
Mouse Monoclonal [clone ABM3A87] (IgG1,k) to Human TLR2
Mouse, Human
Flo IHC IHC-P WB
Unconjugated
100µl 0.5mg/ml  $425.00
Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)

TLR2 Antibody (aa595-760) LS-C296700
Rabbit Polyclonal (IgG) to Rat TLR2
Rat
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $295.00; 1ml 0.5mg/ml  $515.00; 10ml 0.5mg/ml  $2,040.00
Western blot of recombinant TLR2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant TLR2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

TLR2 Antibody (clone T2.5) LS-C139892
Mouse Monoclonal [clone T2.5] (IgG1) to Mouse TLR2
Mouse, Human
Flo Func IF IHC IHC-Fr IP
Unconjugated
100µg 0.1mg/ml  $560.00

TLR2 Antibody LS-C10686
Mouse Monoclonal (IgG2a) to Mouse TLR2
Mouse
ELISA Flo IHC IHC-Fr IP
Unconjugated
100µg 0.1mg/ml  $710.00

TLR2 Antibody LS-C393195
Rabbit Polyclonal to Human TLR2
Mouse, Bovine, Rat, Human
IF IHC IHC-P WB
Unconjugated
100µl  $305.00

TLR2 Antibody LS-C10647
Mouse Monoclonal (IgG2a) to Human TLR2
Human, Monkey
Flo IHC IHC-Fr IP
Unconjugated
100µg 0.5mg/ml  $545.00; 200µg  $905.00

TLR2 Antibody (FITC) LS-C121305
Mouse Monoclonal (IgG2a) to Human TLR2
Human, Monkey, Cynomolgus
Flo IHC IHC-Fr IHC-P IP WB
FITC Conjugated
100µg 0.1mg/ml  $800.00

TLR2 Antibody LS-C124673
Mouse Monoclonal (IgG2a) to Human TLR2
Human
Flo IHC IHC-Fr
Unconjugated
100µg 0.5mg/ml  $560.00

TLR2 Antibody LS-C10648
Mouse Monoclonal (IgG2a) to Human TLR2
Human
Flo IHC IHC-Fr
Unconjugated
100µg 0.5mg/ml  $475.00; 200µg  $770.00

TLR2 Antibody (aa400-450, clone IMG11G5) LS-C148813
Rat Monoclonal [clone IMG11G5] (IgG2a,k) to Mouse TLR2
Mouse
Flo WB
Unconjugated
100µg 0.5mg/ml  $335.00

TLR2 Antibody LS-C408202
Rabbit Polyclonal (IgG) to Human TLR2
Mouse, Rat, Human
ICC IP WB
Unconjugated
50µl  $315.00; 100µl  $425.00; 200µl  $650.00
Western blot analysis of extracts of various cell lines, using TLR2 antibody. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking.
Western blot analysis of extracts of various cell lines, using TLR2 antibody. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking.

TLR2 Antibody (clone 11G7, Biotin) LS-C62844
Mouse Monoclonal [clone 11G7] (IgG) to Human TLR2
Human
ELISA Flo IP
Biotin Conjugated
100µg 0.1mg/ml  $255.00

TLR2 Antibody LS-C10661
Mouse Monoclonal (IgG2a) to Human TLR2
Human
Flo
Unconjugated
100µg 0.5mg/ml  $475.00

TLR2 Antibody (clone mT2.7, PE) LS-C105817
Mouse Monoclonal [clone mT2.7] (IgG2a,k) to Mouse TLR2
Mouse
Flo
PE Conjugated
25µg  $245.00; 100µg 0.2mg/ml  $395.00
Staining of C57Bl/6 splenocytes with FITC anti-mouse/human CD11b (M1/70) (LS-C107132) and 0.125 ug PE Mouse IgG2a isotype control. Total viable cells were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Staining of C57Bl/6 splenocytes with FITC anti-mouse/human CD11b (M1/70) (LS-C107132) and 0.125 ug PE anti-mouse TLR2 (mT2.7). Total viable cells were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Staining of C57Bl/6 splenocytes with FITC anti-mouse/human CD11b (M1/70) (LS-C107132) and 0.125 ug PE Mouse IgG2a isotype control. Total viable cells were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Staining of C57Bl/6 splenocytes with FITC anti-mouse/human CD11b (M1/70) (LS-C107132) and 0.125 ug PE anti-mouse TLR2 (mT2.7). Total viable cells were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.

TLR2 Antibody (aa564-580) LS-C753
Rabbit Polyclonal (IgG) to Mouse TLR2
Mouse, Human
WB
Unconjugated
100µg 200µl 0.5mg/ml  $335.00
Western blot of TLR2 in (A) 15 ugs of Raw cell lysate (B) mouse TLR2 transfected cell lysate and (C) Ramos cell lysate using antibody at 1 ug/ml.
Western blot of TLR2 in (A) 15 ugs of Raw cell lysate (B) mouse TLR2 transfected cell lysate and (C) Ramos cell lysate using antibody at 1 ug/ml.

TLR2 Antibody LS-C752
Rabbit Polyclonal (IgG) to Mouse TLR2
Mouse
WB
Unconjugated
100µg 200µl 0.5mg/ml  $335.00
Western blot of mTLR2 in 15 ul/lane of transfected cell lysate using antibody at 1 ug/ml.
Western blot of mTLR2 in 15 ul/lane of transfected cell lysate using antibody at 1 ug/ml.

TLR2 Antibody (clone TL2.1) LS-C139995
Mouse Monoclonal [clone TL2.1] (IgG2a) to Human TLR2
Dog, Human
Flo Func IF IHC IHC-Fr IHC-P IP WB
Unconjugated
100µg 0.1mg/ml  $425.00
Showing 1-25 of 280 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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