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TLE1 / TLE 1

transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)

Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.

Gene Name:	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
Synonyms:	TLE1, E(Sp1) homolog, ESG, GRG1, Enhancer of split groucho 1, ESG1
Target Sequences:	NM_005077 NP_005068.2 Q04724

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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