TICAM2 / TRAM

toll-like receptor adaptor molecule 2

Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.

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Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

TICAM2 / TRAM (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His-GST (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Mouse (1)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (3)

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Human TICAM2 / TRAM Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67415

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.7 kDa

Price:

20 µg/$1,107

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Human TICAM2 / TRAM Protein (Recombinant GST, N-terminus) (aa1-235) - LS-G56808

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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TICAM2 / TRAM Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101754

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.7 kDa

Price:

100 µg/$494

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Human TICAM2 / TRAM Protein (Recombinant His-T7) (aa34-241) - LS-G15818

Source:

E. coli

Tag:

His-T7

Molecular Weight:

24.7 kDa

Price:

10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252

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Mouse TICAM2 / TRAM Protein (Recombinant His-GST) (aa20-196) - LS-G25834

Source:

E. coli

Tag:

His-GST

Molecular Weight:

49.9 kDa

Price:

10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231

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Human TICAM2 / TRAM Protein (Recombinant His) - LS-G1622

Source:

E. coli

Tag:

His

Price:

50 µg/$361; 250 µg/$739; 10 µg/$261

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Human TICAM2 / TRAM Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79788

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.7 kDa

Price:

20 µg/$150

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Human TICAM2 / TRAM Protein (Recombinant GST) (Full Length) - LS-G37360

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

53.3 kDa

Price:

10 µg/$479; 25 µg/$670

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