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TICAM2 / TRAM

toll-like receptor adaptor molecule 2

Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.

Gene Name: toll-like receptor adaptor molecule 2
Synonyms: TICAM2, Cytoplasmic adaptor, TRIF-related adapter molecule, TIRAP3, TRIF-related adaptor molecule, TICAM-2, TIRP, TRAM
Target Sequences: NM_021649 NP_067681.1 Q86XR7

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Products
Proteins (8)
Over-Expression Lysate (2)
Recombinant (6)
TICAM2 / TRAM (8)
No (8)
GST (1)
GST, N-terminus (1)
His (1)
His-GST (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (6)
Mouse (1)
293T Cells (1)
E. coli (4)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (3)
TICAM2 / TRAM Protein - Purified recombinant protein TICAM2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
26.7 kDa
20 µg/$1,107
TICAM2 / TRAM Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
GST, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
TICAM2 / TRAM Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
26.7 kDa
100 µg/$494
TICAM2 / TRAM Protein - Recombinant Toll Like Receptor Adaptor Molecule 2 By SDS-PAGE
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E. coli
His-T7
24.7 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
TICAM2 / TRAM Protein - Recombinant Toll Like Receptor Adaptor Molecule 2 By SDS-PAGE
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E. coli
His-GST
49.9 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
TICAM2 / TRAM Protein
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E. coli
His
50 µg/$361; 250 µg/$739; 10 µg/$261
TICAM2 / TRAM Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
26.7 kDa
20 µg/$150
TICAM2 / TRAM Protein - 12.5% SDS-PAGE of human TICAM2 stained with Coomassie Blue
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Wheat Germ Extract
GST
53.3 kDa
10 µg/$479; 25 µg/$670
Viewing 1-8 of 8 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).