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Thyrotropin / TSH

TSH / Thyrotropin

Thyroid-stimulating hormone (thyrotropin, TSH) is a glycoprotein hormone produced in the pituitary gland. TSH serves to stimulate the thyroid to produce thyroxine and its converted product triiodothyronine, which in turn stimulate metabolism throughout the body. High levels of TSH are secreted during stress, development and rapid growth. TSH is a heterodimer, and the beta subunit (TSHB) is unique to thyroid-stimulating hormone, while the alpha subunit (TSHA) is identical across chorionic gonadotropin, luteinizing hormone and follicle-stimulating hormone. Levels of TSH are commonly measured to determine degree of thyroid function and to diagnose diseases of the thyroid. In immunohistochemistry, antibodies to TSH are used to identify and subtype pituitary adenomas; roughly 1% of pituitary adenomas have been found to secrete excess TSH, which leads to downstream overproduction of thyroid hormones and consequently hyperthyroidism. In normal tissue, TSH has positive cytoplasmic staining in anterior pituitary endocrine cells.

Thyrotropin / TSH Target Details

Target Name: TSH / Thyrotropin
Target Abbreviation: TSH

Publications (5)

1
Downregulation of the GHRH/GH/IGF1 axis in a mouse model of Börjeson-Forssman-Lehman syndrome. Helen M McRae, Samantha Eccles, Lachlan Whitehead, Warren S Alexander, Jozef Gécz, Tim Thomas, Anne K Voss. Development (Cambridge, England). 2020 October;147: [Full Text Article] [PubMed:32994169]
2
Leptin regulation of core body temperature involves mechanisms independent of the thyroid axis. Jennifer D Deem, Kenjiro Muta, Kayoko Ogimoto, Jarrell T Nelson, Kevin R Velasco, Karl J Kaiyala, Gregory J Morton. American journal of physiology. Endocrinology and metabolism. 2018 October;315:E552-E564. [Full Text Article] [PubMed:29944392] [PMC:PMC6230702]
3
Downregulation of the GHRH/GH/IGF1 axis in a mouse model of Börjenson-Forssman-Lehman syndrome. Helen M. McRae, Samantha Eccles, Lachlan Whitehead, Warren S. Alexander, Jozef Gécz, Tim Thomas, Anne K. Voss. Development (Cambridge, England). 2020 October;147:dev187021. [Full Text Article] [PubMed:34004896]
4
Therapeutic Potential of MgO and MnO Nanoparticles Within the Context of Thyroid Profile and Pancreatic Histology in a Diabetic Rat Model. Arslan Shaukat, Ghulam Hussain, Shahzad Irfan, Muhammad Umar Ijaz, Haseeb Anwar. Dose-response : a publication of International Hormesis Society. 2022 September;20:15593258221128743. [Full Text Article] [PubMed:36158742] [PMC:PMC9500299]
5
Impact of chronic variable stress on neuroendocrine hypothalamus and pituitary in male and female C57BL/6J mice. Betina B Nair, Zin Khant Aung, Robert Porteous, Melanie Prescott, Kelly A Glendining, Danielle E Jenkins, Rachael A Augustine, Mauro S B Silva, Siew H Yip, Gregory T Bouwer, Colin H Brown, Christine L Jasoni, Rebecca E Campbell, Stephen J Bunn, Greg M Anderson, David R Grattan, Allan E Herbison, Karl J Iremonger. Journal of neuroendocrinology. 2021 May;33:e12972. [Full Text Article] [PubMed:33896057]
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).