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Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk.
Gene Name: | thymocyte selection associated |
Synonyms: | THEMIS, C6orf207, C6orf190, BA325O24.3, GRB2-associated protein, Protein THEMIS, SPOT, Thymocyte selection associated, BA325O24.4, TSEPA, GASP |
Target Sequences: | NP_848781.1 Q8BGW0 |
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