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THBS1 / Thrombospondin-1
thrombospondin 1
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors.
| Gene Name: | thrombospondin 1 |
| Synonyms: | THBS1, Thrombospondin-1, Thrombospondin-1p180, TSP, TSP1, THBS-1, THBS, Thrombospondin 1, TSP-1 |
| Target Sequences: | NM_003246 NP_003237.2 P07996 |
Publications (6)
1
Activation of the ROCK1 Branch of the Transforming Growth Factor-² Pathway Contributes to RAGE-Dependent Acceleration of Atherosclerosis in Diabetic ApoE-Null Mice. De-xiu Bu, Vivek Rai, Xiaoping Shen, Rosa Rosario, Yan Lu, Vivette D'Agati, Shi Fang Yan, Richard A. Friedman, Edem Nuglozeh and Ann Marie Schmidt. Circulation research. 2010 106:1040-51. (WB; Mouse)
[Full Text Article]
[PubMed:20133903]
[PMC:PMC2848909]
2
Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. Schips TG, Vanhoutte D, Vo A, Correll RN, Brody MJ, Khalil H, Karch J, Tjondrokoesoemo A, Sargent MA, Maillet M, Ross RS, Molkentin JD. Nature communications. 2019 January;10:76. [Full Text Article]
[PubMed:30622267]
[PMC:PMC6325143]
Related Antibodies: LS-B4155.
3
SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells. Wiley CD, Liu S, Limbad C, Zawadzka AM, Beck J, Demaria M, Artwood R, Alimirah F, Lopez-Dominguez JA, Kuehnemann C, Danielson SR, Basisty N, Kasler HG, Oron TR, Desprez PY, Mooney SD, Gibson BW, Schilling B, Campisi J, Kapahi P. Cell reports. 2019 September;28:3329-3337.e5. [Full Text Article]
[PubMed:31553904]
[PMC:PMC6907691]
☰ Filters
Products
Proteins
(20)
Type
Over-Expression Lysate
(2)
Recombinant
(18)
Target
THBS1 / Thrombospondin-1
(20)
Publications
No
(19)
Yes
(1)
Tag
His
(10)
His, C-Terminal
(1)
His, C-terminus
(1)
His, N-Terminal
(2)
His,C-terminus
(1)
Human IgG1 Fc, N-terminus
(1)
Myc-DDK (Flag)
(3)
Species
Bovine
(1)
Human
(8)
Mouse
(6)
Rat
(4)
Source
293T Cells
(1)
E. coli
(12)
HEK 293 Cells
(3)
Human
(1)
Insect Cells
(1)
Mammalian Cells
(1)
Yeast
(1)
Purification
Purified
(2)
Low Endotoxin Level
Low endotoxin level
(5)
E. coli
His
26.3 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
E. coli
His, N-Terminal
23.4 kDa
10 µg/$279; 50 µg/$427; 200 µg/$852; 1 mg/$1,950; 5 mg/$2,983; 2 mg/$2,136
E. coli
His
18.8 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
129.2 kDa
10 µg/$277; 50 µg/$389
E. coli
His
21.6 kDa
10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136
E. coli
His, C-terminus
18.2 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
HEK 293 Cells
Human IgG1 Fc, N-terminus
Less than 0.06 EU/µg protein (determined by LAL method).
50 µg/$428
E. coli
His
40.7 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
Yeast
His
38.6 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
E. coli
His
40 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
HEK 293 Cells
Myc-DDK (Flag)
127.4 kDa
20 µg/$1,107
293T Cells
Myc-DDK (Flag)
129.38 kDa
20 µg/$215
HEK 293 Cells
Myc-DDK (Flag)
129.38 kDa
100 µg/$710
E. coli
214 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
23.65 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
Human
His, C-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
129.2kD
50 µg/$395; 500 µg/$1,585; 1 mg/$2,157; 10 µg/$277
Insect Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
~140 kDa
10 µg/$432
E. coli
His, N-Terminal
23.1 kDa
10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
E. coli
His
22.3 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
E. coli
His
18.5 kDa
10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136
E. coli
His
21.5 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
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