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THBS1 / Thrombospondin-1

thrombospondin 1

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors.

Gene Name:	thrombospondin 1
Synonyms:	THBS1, Thrombospondin-1, Thrombospondin-1p180, TSP, TSP1, THBS-1, THBS, Thrombospondin 1, TSP-1
Target Sequences:	NM_003246 NP_003237.2 P07996

Publications (6)

Activation of the ROCK1 Branch of the Transforming Growth Factor-² Pathway Contributes to RAGE-Dependent Acceleration of Atherosclerosis in Diabetic ApoE-Null Mice. De-xiu Bu, Vivek Rai, Xiaoping Shen, Rosa Rosario, Yan Lu, Vivette D'Agati, Shi Fang Yan, Richard A. Friedman, Edem Nuglozeh and Ann Marie Schmidt. Circulation research. 2010 106:1040-51. (WB; Mouse) [Full Text Article] [PubMed:20133903] [PMC:PMC2848909]

Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. Schips TG, Vanhoutte D, Vo A, Correll RN, Brody MJ, Khalil H, Karch J, Tjondrokoesoemo A, Sargent MA, Maillet M, Ross RS, Molkentin JD. Nature communications. 2019 January;10:76. [Full Text Article] [PubMed:30622267] [PMC:PMC6325143] Related Antibodies: LS-B4155.

SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells. Wiley CD, Liu S, Limbad C, Zawadzka AM, Beck J, Demaria M, Artwood R, Alimirah F, Lopez-Dominguez JA, Kuehnemann C, Danielson SR, Basisty N, Kasler HG, Oron TR, Desprez PY, Mooney SD, Gibson BW, Schilling B, Campisi J, Kapahi P. Cell reports. 2019 September;28:3329-3337.e5. [Full Text Article] [PubMed:31553904] [PMC:PMC6907691]

Coding transcriptome analyses reveal altered functions underlying immunotolerance of PEG-fused rat sciatic nerve allografts. Tyler A Smith, Cameron L Ghergherehchi, Haley O Tucker, George D Bittner. Journal of neuroinflammation. 2020 October;17:287. [Full Text Article] [PubMed:33008419] [PMC:PMC7532577] Related Antibodies: LS-C137099.

Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity10<sup> Campus Moulin de la Housse, Plateau Technique Mobile en Cytométrie Environnementale MOBICYTE, UFR Sciences Exactes et Naturelles, Université de Reims Champagne-Ardenne/INERIS, 51000 Reims, France. Albin Jeanne , Thomas Sarazin , Magalie Charlé , Catherine Moali, Caroline Fichel, Camille Boulagnon-Rombi , Maïté Callewaert, Marie-Christine Andry, Eric Diesis, Frédéric Delolme , Damien Rioult, Stéphane Dedieu. Cancers. 2021 Oct;13:5019. [Full Text Article] [PubMed:34638503] [PMC:PMC8508526] Related Antibodies: LS-C402945.

Thrombospondin-1 aggravates colonic mucosal inflammatory injuries via promoting the differentiation of CD11c+<sup> macrophages with lysosomal activity limited in colitis. Ping Tao, Beiping Zhang, Jiang Lin, Shiying Wang. Annals of translational medicine. 2021 December;9:1738. [Full Text Article] [PubMed:35071432] [PMC:PMC8743729]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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