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DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
Gene Name: | THAP Domain Containing, Apoptosis Associated Protein 1 |
Synonyms: | THAP1, DYT6, Nuclear proapoptotic factor, THAP domain protein 1 |
Target Sequences: | NM_018105 NP_060575.1 Q9NVV9 |
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