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TGIF2 is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene.
Gene Name: | TGFB-induced factor homeobox 2 |
Synonyms: | TGIF2, 5-TG-3-interacting factor 2, 5-TG-3 interacting factor 2, Homeobox protein TGIF2, TGF beta induced factor 2, TGFB-induced factor 2, TGFB-induced factor homeobox 2 |
Target Sequences: | NM_021809 NP_068581.1 Q9GZN2 |
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