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TGFBR2

transforming growth factor, beta receptor II (70/80kDa)

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

Gene Name: transforming growth factor, beta receptor II (70/80kDa)
Family/Subfamily: Protein Kinase , Activin/TGFb
Synonyms: TGFBR2, AAT3, FAA3, HNPCC6, LDS2B, MFS2, TGF-beta receptor type-2, TGF-beta RII, TGFBRII, TGF-beta type II receptor, TGFbeta-RII, TbetaR-II, TGF beta Receptor II, TGF-beta receptor type II, TGF-beta receptor type IIB, TGFR-2, LDS1B, RIIC, TAAD2
Target Sequences: NM_003242 NP_003233.4 P37173

☰ Filters
Products
Proteins (18)
Over-Expression Lysate (2)
Recombinant (16)
TGFBR2 (18)
SDS-PAGE (2)
No (18)
10His, N-terminus + Myc, C-terminus (1)
6His, C-terminus (2)
Fc (1)
Fc, C-terminus (5)
GST (1)
GST, N-terminus (2)
His (1)
His,C-terminus (1)
Human IgG Fc, C-terminus (1)
Myc-DDK (Flag) (3)
Human (8)
Mouse (6)
Rat (3)
293T Cells (1)
Baculovirus (2)
E. coli (1)
HEK 293 Cells (3)
Human (1)
Human Cells (4)
Mammalian Cells (3)
Wheat Germ Extract (3)
Purified (3)
Low endotoxin level (10)
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.3kD
10 µg/$266; 50 µg/$343; 500 µg/$1,377; 1 mg/$1,765
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
16.2kD
10 µg/$266; 50 µg/$343; 500 µg/$1,869; 1 mg/$2,991
TGFBR2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Baculovirus
10His, N-terminus + Myc, C-terminus
100 µg/$810; 20 µg/$387; 1 mg/$1,678
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
16.2 kDa
10 µg/$266; 50 µg/$339
Select
Baculovirus
His,C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human TGFBR2 consists of 154 amino acids and predicts a molecular mass of 17.7 kDa.
100 µg/$441; 1 mg/$2,003
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.3 kDa
10 µg/$266; 50 µg/$339
TGFBR2 Protein - 12.5% SDS-PAGE of human TGFBR2 stained with Coomassie Blue
Select
Wheat Germ Extract
GST, N-terminus
62.48 kDa
10 µg/$479; 25 µg/$670
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.6kD
10 µg/$321; 50 µg/$534; 500 µg/$1,869; 1 mg/$2,991
TGFBR2 Protein
Select
HEK 293 Cells
Human IgG Fc, C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant rat TGFBR2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 384 amino acids and has a predicted molecular mass of 43 kDa. The apparent molecular mass of the protein is approximately 54 kDa in SDS-PAGE under reducing conditions.
100 µg/$441
TGFBR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
64.57 kDa
100 µg/$710
TGFBR2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
TGFBR2 Protein - Purified recombinant protein TGFBR2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
62 kDa
20 µg/$1,107
TGFBR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
64.57 kDa
20 µg/$215
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
43 kDa
100 µg/$721
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.6 kDa
10 µg/$317; 50 µg/$524
TGFBR2 Protein - Recombinant Mouse Transforming Growth Factor-Beta Receptor Type II/TGFBR2 (C-Fc)
Select
Human
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
45 kDa
10 µg/$337; 50 µg/$621
TGFBR2 Protein - Recombinant Transforming Growth Factor Beta Receptor II By SDS-PAGE
Select
E. coli
His
47.5 kDa
10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225
TGFBR2 Protein - 12.5% SDS-PAGE of human TGFBR2 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
91 kDa
10 µg/$479; 25 µg/$670
Viewing 1-18 of 18 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).