TGFBR2

transforming growth factor, beta receptor II (70/80kDa)

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

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Products

Proteins (18)

Type

Over-Expression Lysate (2)

Recombinant (16)

Target

TGFBR2 (18)

Application

SDS-PAGE (2)

Publications

No (18)

Tag

10His, N-terminus + Myc, C-terminus (1)

6His, C-terminus (2)

Fc (1)

Fc, C-terminus (5)

GST (1)

GST, N-terminus (2)

His (1)

His,C-terminus (1)

Human IgG Fc, C-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (8)

Mouse (6)

Rat (3)

Source

293T Cells (1)

Baculovirus (2)

E. coli (1)

HEK 293 Cells (3)

Human (1)

Human Cells (4)

Mammalian Cells (3)

Wheat Germ Extract (3)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (10)

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Mouse TGFBR2 Protein (Recombinant 6His, C-terminus) (Ile24-Asp159) - LS-G40156

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

16.2kD

Price:

10 µg/$266; 50 µg/$343; 500 µg/$1,869; 1 mg/$2,991

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Mouse TGFBR2 Protein (Recombinant Fc, C-terminus) (Ile24-Asp159) - LS-G40155

Source:

Human Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

42.3kD

Price:

10 µg/$266; 50 µg/$343; 500 µg/$1,377; 1 mg/$1,765

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Rat TGFBR2 Protein (Recombinant 10His, N-terminus + Myc, C-terminus) (aa24-166) - LS-G55970

Source:

Baculovirus

Tag:

10His, N-terminus + Myc, C-terminus

Price:

100 µg/$810; 20 µg/$387; 1 mg/$1,678

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Human TGFBR2 Protein (Recombinant His,C-terminus) - LS-G141195

Source:

Baculovirus

Tag:

His,C-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human TGFBR2 consists of 154 amino acids and predicts a molecular mass of 17.7 kDa.

Price:

100 µg/$441; 1 mg/$2,003

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Mouse TGFBR2 Protein (Recombinant 6His, C-terminus) (Ile24-Asp159) - LS-G138857

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

16.2 kDa

Price:

10 µg/$266; 50 µg/$339

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Human TGFBR2 Protein (Recombinant GST, N-terminus) (Full Length) - LS-G30692

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Molecular Weight:

62.48 kDa

Price:

10 µg/$479; 25 µg/$670

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Rat TGFBR2 Protein (Recombinant Human IgG Fc, C-terminus) (Met1-Gln166) - LS-G49969

Source:

HEK 293 Cells

Tag:

Human IgG Fc, C-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant rat TGFBR2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 384 amino acids and has a predicted molecular mass of 43 kDa. The apparent molecular mass of the protein is approximately 54 kDa in SDS-PAGE under reducing conditions.

Price:

100 µg/$441

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Mouse TGFBR2 Protein (Recombinant Fc, C-terminus) (Ile24-Asp159) - LS-G138858

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

42.3 kDa

Price:

10 µg/$266; 50 µg/$339

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Human TGFBR2 Protein (Recombinant Fc, C-terminus) (Thr23-Asp159) - LS-G39382

Source:

Human Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

42.6kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,869; 1 mg/$2,991

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Human TGFBR2 Protein (Recombinant GST, N-terminus) (aa62-165) - LS-G60345

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Mouse TGFBR2 Protein (Recombinant Fc, C-terminus) - LS-G146261

Source:

Human

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

45 kDa

Price:

10 µg/$337; 50 µg/$621

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Human TGFBR2 Protein (Recombinant GST) (Full Length) - LS-G30695

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

91 kDa

Price:

10 µg/$479; 25 µg/$670

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Mouse TGFBR2 Protein (Recombinant His) (aa209-590) - LS-G25186

Source:

E. coli

Tag:

His

Molecular Weight:

47.5 kDa

Price:

10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225

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Human TGFBR2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67100

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

62 kDa

Price:

20 µg/$1,107

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Human TGFBR2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79132

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

64.57 kDa

Price:

20 µg/$215

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TGFBR2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99999

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

64.57 kDa

Price:

100 µg/$710

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Human TGFBR2 Protein (Recombinant Fc, C-terminus) (Thr23-Asp159) - LS-G140516

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

42.6 kDa

Price:

10 µg/$317; 50 µg/$524

Select

Rat TGFBR2 Protein (Recombinant Fc) (Met1-Gln166) - LS-G98481

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

43 kDa

Price:

100 µg/$721

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