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TGFBR2

transforming growth factor, beta receptor II (70/80kDa)

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

Gene Name: transforming growth factor, beta receptor II (70/80kDa)
Family/Subfamily: Protein Kinase , Activin/TGFb
Synonyms: TGFBR2, AAT3, FAA3, HNPCC6, LDS2B, MFS2, TGF-beta receptor type-2, TGF-beta RII, TGFBRII, TGF-beta type II receptor, TGFbeta-RII, TbetaR-II, TGF beta Receptor II, TGF-beta receptor type II, TGF-beta receptor type IIB, TGFR-2, LDS1B, RIIC, TAAD2
Target Sequences: NM_003242 NP_003233.4 P37173

☰ Filters
Products
Antibodies (74)
Primary (74)
TGFBR2 (74)
Human (62)
Mouse (52)
Rat (17)
Bat (1)
Bovine (1)
Chicken (2)
Chimpanzee (3)
Gibbon (3)
Guinea pig (1)
Horse (1)
Monkey (5)
Pig (3)
Rabbit (3)
Sheep (1)
IHC (28)
IHC-P (7)
WB (57)
Flo (3)
ELISA (24)
ICC (5)
IF (12)
IP (1)
Peptide-ELISA (6)
rabbit (64)
mouse (4)
goat (4)
sheep (2)
Product Group
IHCPlus (1)
PathPlus Cancer (2)
IgG (46)
IgG1 (2)
IgG2a (2)
monoclonal mc (4)
polyclonal pc (70)
OTI3B4 (2)
OTI4F3 (2)
APC (1)
APC Conjugated (4)
Azide-free (2)
Biotin Conjugated (6)
Carrier-free (2)
CF Conjugated (1)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (3)
PerCP Conjugated (1)
Unconjugated (47)
aa209-590 (8)
aa13-40 (7)
aa548-575 (7)
N-Terminus (4)
aa23-294 (4)
Extracellular Domain (3)
Internal (2)
pSer225 (2)
160-240 aa (1)
60-140 aa, Internal (1)
Glu246 (1)
aa100-150 (1)
aa191-240 (1)
aa25-159 (1)
aa27-85 (1)
aa330-346 (1)
aa475-525 (1)
aa517-567 (1)
aa73-122 (1)
aa77-148 (1)
aa91-140 (1)
aa96-128 (1)
p250 (1)
pSer225/250 (1)
pSer225/Ser250 (1)
No (74)
TGFBR2 Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer
TGFBR2 Rabbit anti-Human Polyclonal (aa13-40) Antibody
Mouse, Human
IF, IHC-P, WB
Unconjugated
200 µl/$460
Select
TGFBR2 Goat anti-Mouse Polyclonal (APC) Antibody
Mouse
Flo
APC Conjugated
100 Tests/$896
TGFBR2 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer
TGFBR2 Rabbit anti-Human Polyclonal (aa517-567) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
TGFBR2 Antibody - Immunohistochemical analysis of TGFBR2 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected with HRP and DAB as chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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TGFBR2 Rabbit anti-Human Polyclonal (Internal) Antibody
Rabbit, Mouse, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
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TGFBR2 Goat anti-Mouse Polyclonal (Extracellular Domain) (PerCP) Antibody
Mouse
Flo
PerCP Conjugated
100 Tests/$859
TGFBR2 Antibody - Western blot of p-TGFBR2 (S225/250) antibody at 1:500 dilution. Lane 1: HEK293T cell lysate treated with EGF(0.1ng/ml,30mins). Lane 2: Raw264.7 cell lysate treated with EGF(0.1ng/ml,30mins). Lane 3: H9C2 cell lysate treated with EGF(0.1ng/ml,30mins).
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TGFBR2 Rabbit anti-Human Polyclonal (pSer225) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$431
TGFBR2 Antibody - Immunohistochemistry of paraffin-embedded human liver cancer using TGFBR2 antibody at dilution of 1:100 (40x lens).
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TGFBR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
TGFBR2 Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-TGFBR2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:2000)
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TGFBR2 Mouse anti-Human Monoclonal (aa23-294) (OTI3B4) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
TGFBR2 Antibody - IHC of TGF RII (E246) pAb in paraffin-embedded human brain tissue.
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TGFBR2 Rabbit anti-Human Polyclonal (Glu246) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
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TGFBR2 Rabbit anti-Human Polyclonal (aa475-525) Antibody
Human
IP
Unconjugated
10 µg/$295; 100 µl/$514
Select
TGFBR2 Rabbit anti-Human Polyclonal (aa13-40) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
200 µl/$734
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TGFBR2 Rabbit anti-Mouse Polyclonal (aa13-40) (Biotin) Antibody
Mouse
ELISA, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
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TGFBR2 Rabbit anti-Mouse Polyclonal (aa13-40) (FITC) Antibody
Mouse
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
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TGFBR2 Rabbit anti-Mouse Polyclonal (aa13-40) (PE) Antibody
Mouse
ELISA, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
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TGFBR2 Rabbit anti-Mouse Polyclonal (aa13-40) (APC) Antibody
Mouse
ELISA, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
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TGFBR2 Rabbit anti-Mouse Polyclonal (aa13-40) (Azide-free) (HRP) Antibody
Mouse
ELISA, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
TGFBR2 Antibody - Western blot analysis of lysates from HepG2 (65K) cells, using TGF beta Receptor II Antibody. The lane on the right is blocked with the synthesized peptide.
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TGFBR2 Rabbit anti-Human Polyclonal (aa91-140) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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TGFBR2 Goat anti-Mouse Polyclonal (Extracellular Domain) (CF) Antibody
Mouse
Flo
CF Conjugated
100 Tests/$709
Select
TGFBR2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$341
TGFBR2 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
TGFBR2 Rabbit anti-Human Polyclonal (aa100-150) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
TGFBR2 Antibody - Immunohistochemistry of paraffin-embedded human brain tissue using TGFBR2 Antibody at dilution of 1:100
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TGFBR2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
Select
TGFBR2 Rabbit anti-Human Polyclonal (aa25-159) (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
TGFBR2 Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer using TGFBR2 Polyclonal Antibody at dilution of 1:100 (40x lens).
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TGFBR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
TGFBR2 Antibody - Immunohistochemistry analysis of paraffin-embedded human brain tissue, using TGF beta Receptor II Antibody. The picture on the right is blocked with the synthesized peptide.
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TGFBR2 Rabbit anti-Human Polyclonal (aa191-240) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
TGFBR2 Antibody - 1:100 staining human urothelial carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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TGFBR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Viewing 1-25 of 74 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).