TGFBR1 / ALK5

transforming growth factor, beta receptor 1

Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.

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Products

Proteins (9)

Type

Over-Expression Lysate (2)

Recombinant (7)

Target

TGFBR1 / ALK5 (9)

Publications

No (9)

Tag

Fc, C-terminus (2)

GST, N-terminus (1)

His-Fc (1)

His-GST (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Mouse (1)

Source

293T Cells (1)

Baculovirus (1)

E. coli (1)

HEK 293 Cells (3)

Human (2)

Wheat Germ Extract (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (4)

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Human TGFBR1 / ALK5 Protein (Recombinant His-GST) (Thr200-Mey503) - LS-G97152

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

62.6 kDa

Price:

50 µg/$707

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Human TGFBR1 / ALK5 Protein (Recombinant His-Fc) (Met1-Glu125) - LS-G97943

Source:

HEK 293 Cells

Tag:

His-Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

38.8 kDa

Price:

100 µg/$710

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Human TGFBR1 / ALK5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78778

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.96 kDa

Price:

20 µg/$215

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Human TGFBR1 / ALK5 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66941

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.6 kDa

Price:

20 µg/$1,107

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Human TGFBR1 / ALK5 Protein (Recombinant GST, N-terminus) (aa30-125) - LS-G60343

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Mouse TGFBR1 / ALK5 Protein (Recombinant Fc, C-terminus) - LS-G146252

Source:

Human

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

37.6 kDa

Price:

10 µg/$337; 50 µg/$621

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Human TGFBR1 / ALK5 Protein (Recombinant Fc, C-terminus) - LS-G146045

Source:

Human

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

37.2 kDa

Price:

10 µg/$337; 50 µg/$621

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TGFBR1 / ALK5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100341

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.96 kDa

Price:

100 µg/$710

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Human TGFBR1 / ALK5 Protein (Recombinant His-T7) (aa162-403) - LS-G12111

Source:

E. coli

Tag:

His-T7

Molecular Weight:

31.1 kDa

Price:

50 µg/$460; 10 µg/$284; 200 µg/$917; 100 µg/$735; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225

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