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TFF3 / Trefoil Factor 3

trefoil factor 3 (intestinal)

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. TFF3 is expressed in goblet cells of the intestines and colon. The TFF3 gene consists of 3 exons, with exon 2 encoding the trefoil domain. The TFF1, TFF2, and TFF3 genes are located within a 55 kb region, suggesting they evolved from a common ancestor by duplication.

Gene Name: trefoil factor 3 (intestinal)
Synonyms: TFF3, HP1.B, Intestinal trefoil factor, HITF, ITF, TFI, p1B, Polypeptide P1.B, Trefoil factor 3, Trefoil factor 3 (intestinal)
Target Sequences: NM_003226

Publications (2)

1
Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating Tff3 Expression. Zhu Y, Zhao S, Deng Y, Gordillo R, Ghaben AL, Shao M, Zhang F, Xu P, Li Y, Cao H, Zagnitko O, Scott DA, Gupta RK, Xing C, Zhang BB, Lin HV, Scherer PE. Diabetes. 2017 November;66:2789-2799. [Full Text Article] [PubMed:28877911] [PMC:PMC5652600]
2
A reinforcing HNF4-SMAD4 feed-forward module stabilizes enterocyte identity. Lei Chen, Natalie H Toke, Shirley Luo, Roshan P Vasoya, Robert L Fullem, Aditya Parthasarathy, Ansu O Perekatt, Michael P Verzi. Nature genetics. 2019 May;51:777-785. [Full Text Article] [PubMed:30988513] [PMC:PMC6650150] Related Antibodies: LS-C662731.

☰ Filters
Products
Proteins (20)
Over-Expression Lysate (2)
Recombinant (18)
TFF3 / Trefoil Factor 3 (20)
No (20)
6His, N-terminus + Mouse IgG Fc, C-terminus (1)
GST (1)
His (1)
His, C-Terminal (1)
His, N-Terminal (1)
His,C-terminus (1)
His-GST (4)
His-GST-S (1)
His-MBP (2)
Myc-DDK (Flag) (2)
TRX-6His, N-terminus (1)
Bovine (1)
Dog (1)
Human (8)
Mouse (5)
Pig (3)
Rat (1)
293T Cells (1)
E. coli (14)
HEK 293 Cells (2)
Human (1)
Mammalian Cells (1)
Wheat Germ Extract (1)
Purified (7)
Low endotoxin level (5)
Biologically active (4)
TFF3 / Trefoil Factor 3 Protein - Recombinant Trefoil Factor 3, Intestinal By SDS-PAGE
Select
E. coli
His-MBP
53.1 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
TFF3 / Trefoil Factor 3 Protein - Recombinant Trefoil Factor 3, Intestinal By SDS-PAGE
Select
E. coli
His-MBP
53.1 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
TFF3 / Trefoil Factor 3 Protein - Recombinant  Trefoil Factor 3, Intestinal By SDS-PAGE
Select
E. coli
His-GST-S
36.5 kDa
10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278
Select
E. coli
None
Biologically active
13.2 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
TFF3 / Trefoil Factor 3 Protein - Recombinant Trefoil Factor 3, Intestinal By SDS-PAGE
Select
E. coli
His-GST
33.6 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
TFF3 / Trefoil Factor 3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
14.25 kDa
100 µg/$494
Select
E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
6.6 kDa
1 mg/$2,653; 20 µg/$364
TFF3 / Trefoil Factor 3 Protein - 12.5% SDS-PAGE of human TFF3 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
32.23 kDa
10 µg/$479; 25 µg/$670
TFF3 / Trefoil Factor 3 Protein
Select
E. coli
His, N-Terminal
53.1 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
TFF3 / Trefoil Factor 3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
14.25 kDa
20 µg/$150
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
13.2 kDa
5 µg/$268; 20 µg/$349
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~6.8 kDa
20 µg/$291; 100 µg/$597; 1 mg/$2,551
Select
Human
His, C-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
7.3kD
10 µg/$277; 50 µg/$376; 500 µg/$1,484; 1 mg/$2,157
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
7.3 kDa
10 µg/$277; 50 µg/$371
TFF3 / Trefoil Factor 3 Protein
Select
E. coli
TRX-6His, N-terminus
26.4 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Select
E. coli
His-GST
33.5 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
TFF3 / Trefoil Factor 3 Protein - Recombinant Trefoil Factor 3, Intestinal By SDS-PAGE
Select
E. coli
His-GST
38.5 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
TFF3 / Trefoil Factor 3 Protein - Recombinant Trefoil Factor 3, Intestinal By SDS-PAGE
Select
E. coli
His-GST
40.3 kDa
10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136
TFF3 / Trefoil Factor 3 Protein - Recombinant Trefoil Factor 3, Intestinal By SDS-PAGE
Select
E. coli
His
5.9 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
TFF3 / Trefoil Factor 3 Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
Select
HEK 293 Cells
6His, N-terminus + Mouse IgG Fc, C-terminus
37-45 kDa
100 µg/$432; 250 µg/$726; 500 µg/$1,270; 1000 µg/$1,799
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).