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Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site.
Gene Name: | transcription factor binding to IGHM enhancer 3 |
Synonyms: | TFE3, BHLHe33, Transcription factor E3, RCCX1, TFEA, RCCP2 |
Target Sequences: | NM_006521 NP_006512.2 P19532 |
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