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Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and apoptosis.
Gene Name: | transcription factor Dp-1 |
Synonyms: | TFDP1, Dp-1, DRTF1, Transcription factor Dp-1, DP1, DRTF1-polypeptide 1, E2F dimerization partner 1 |
Target Sequences: | NM_007111 NP_009042.1 Q14186 |
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