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S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.
Gene Name: | transcription factor B1, mitochondrial |
Synonyms: | TFB1M, CGI-75, H-mtTFB, H-mtTFB1, HTFB1M, MtTFB1, MtTFB, CGI75 |
Target Sequences: | NM_016020 NP_057104.2 Q8WVM0 |
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