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Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation.
Gene Name: | transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) |
Family/Subfamily: | Transcription Factor |
Synonyms: | TFAP2E, AP2-epsilon, AP2E |
Target Sequences: | NM_178548 NP_848643.2 Q6VUC0 |
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