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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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TFAP2A / AP-2

transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. Caution: AP-2B refers to both an alternatively spliced form of AP-2 and to the related transcription factor AP-2 beta.

Gene Name: transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
Synonyms: TFAP2A, Activator protein 2, AP-2, AP-2a, AP2TF, AP-2alpha, BOFS, TFAP2, Transcription factor AP-2, AP-2 transcription factor, AP2-alpha
Target Sequences: NM_003220 NP_003211.1 P05549

Publications (2)

1
Inhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP-2. Zarelli VE, Dawid IB. Proceedings of the National Academy of Sciences of the United States of America. 2013 110:2870-5. (WB, IP; Zebrafish) [Full Text Article] [PubMed:23382213] Related Antibodies: LS-C87212.
2
Dual control of pcdh8l/PCNS expression and function in Xenopus laevis neural crest cells by adam13/33 via the transcription factors tfap2a and arid3a. Khedgikar V, Abbruzzese G, Mathavan K, Szydlo H, Cousin H, Alfandari D. eLife. 2017 6: (WB; Human) [Full Text Article] [PubMed:28829038] [PMC:PMC5601995] Related Antibodies: LS-C624.

Viewing 1-25 of 45 items
TFAP2A / AP-2 Antibody - Anti-TFAP2A / AP2 Alpha antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Neuroscience
Mouse Monoclonal [clone 2G5] (IgG1,k) to Human TFAP2A / AP-2
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   $495.00
TFAP2A / AP-2 Antibody - Anti-TFAP2A / AP2 Alpha antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Goat Polyclonal (IgG) to Human TFAP2A / AP-2
Chicken, Mouse, Dog, Rat, Chimpanzee, Orangutan, Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50µg   1mg/ml   $485.00
Select
Goat Polyclonal to Zebrafish TFAP2A / AP-2
Zebrafish
Peptide-ELISA
Unconjugated
100µg   0.5mg/ml   $335.00
TFAP2A / AP-2 Antibody - Western blot of AP-2 in MCF-7 cell lysate with antibody. A protein band of an approximate molecular weight of 55 kD is detected.
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Rabbit Polyclonal (IgG) to Human TFAP2A / AP-2
Xenopus, Rat, Mouse, Dog, Sheep, Bovine, Human, Monkey
WB
Unconjugated
100µg   200µl   0.5mg/ml   $335.00
TFAP2A / AP-2 Antibody - Immunofluorescence analysis of Hela cells using TFAP2A mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher
Select
Mouse Monoclonal [clone 2H9B5] (IgG1) to Human TFAP2A / AP-2
Human
ELISA, Flo, ICC, IHC, WB
Unconjugated
100µl   $365.00
TFAP2A / AP-2 Antibody - 1:100 staining mouse brain tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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Rabbit Polyclonal (IgG) to Human TFAP2A / AP-2
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
TFAP2A / AP-2 Antibody - 1:100 staining human Skin carcinoma tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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Rabbit Polyclonal (IgG) to Human TFAP2A / AP-2
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
TFAP2A / AP-2 Antibody - Western blot analysis using TFAP2A mAb against HEK293 (1) and TFAP2A (AA: 105-211)-hIgGFc transfected HEK293 (2) cell lysate.
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Mouse Monoclonal [clone 2H9F12] (IgG1) to Human TFAP2A / AP-2
Human
ELISA, Flo, WB
Unconjugated
100µl   $365.00
Select
Mouse Monoclonal (IgG1,k) to Human TFAP2A / AP-2
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100µg   $635.00
Select
Mouse Monoclonal (IgG1,k) to Human TFAP2A / AP-2
Human
ELISA, IHC, WB
HRP Conjugated
100µl   $815.00
Select
Mouse Monoclonal (IgG1,k) to Human TFAP2A / AP-2
Human
ELISA, IHC, WB
Biotin Conjugated
100µl   $815.00
Select
Mouse Monoclonal (IgG1,k) to Human TFAP2A / AP-2
Human
ELISA, IHC, WB
FITC Conjugated
100µl   $815.00
Select
Mouse Monoclonal (IgG1,k) to Human TFAP2A / AP-2
Human
ELISA, IHC, WB
APC Conjugated
100µl   $815.00
Select
Mouse Monoclonal (IgG1,k) to Human TFAP2A / AP-2
Human
ELISA, IHC, WB
AP Conjugated
100µl   $815.00
Select
Mouse Monoclonal (IgG1,k) to Human TFAP2A / AP-2
Human
ELISA, IHC, WB
PE Conjugated
100µl   $815.00
Select
Mouse Monoclonal [clone A6/2/2] (IgG) to Human TFAP2A / AP-2
Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100µg   $950.00
Select
Rabbit Polyclonal to Human TFAP2A / AP-2
Mouse, Rat, Human, Monkey
ELISA, IHC, IHC-P, IP, WB
Unconjugated
100µl   $530.00
Select
Rabbit Polyclonal (IgG) to Human TFAP2A / AP-2
Human
ELISA, IHC, WB
Unconjugated
100µl   $740.00
TFAP2A / AP-2 Antibody - Peptide - + Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using AP-2 antibody.
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Rabbit Polyclonal (IgG) to Human TFAP2A / AP-2
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µg   100µl   1µg/µl   $305.00
TFAP2A / AP-2 Antibody - Western blot of immunized recombinant protein using TFAP2A antibody.
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Mouse Monoclonal [clone 959C2a] (IgG1) to Human TFAP2A / AP-2
Mouse, Human
DB, Flo, WB
Unconjugated
50µg   100µg/ml   $315.00
TFAP2A / AP-2 Antibody - Detection of TFAP2A by Western blot. Samples: Whole cell lysate from human HEK293 (H, 50 ug) and mouse NIH3T3 (M, 50 ug) cells. Predicted molecular weight: 48 kDa
Select
Mouse Monoclonal [clone 959C2a] (IgG1) to Human TFAP2A / AP-2
Mouse, Human
DB, Flo, WB
Unconjugated
100µg   100µg/ml   $415.00
Select
Mouse Monoclonal [clone 1A10C5] (IgG1) to Human TFAP2A / AP-2
Human
ELISA, Flo
Unconjugated
100µl   $365.00
Select
Mouse Monoclonal [clone 7D2B5] (IgG1) to Human TFAP2A / AP-2
Human
ELISA, Flo
Unconjugated
100µl   $365.00
TFAP2A / AP-2 Antibody - IHC of AP-2/ (K431) pAb in paraffin-embedded human lung carcinoma tissue.
Select
Rabbit Polyclonal to Human TFAP2A / AP-2
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100µl   $345.00
Select
Rabbit Polyclonal (IgG) to Human TFAP2A / AP-2
Human
ELISA, WB
Unconjugated
200µl   $590.00

Viewing 1-25 of 45 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).