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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TFAP2A / AP-2

transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. Caution: AP-2B refers to both an alternatively spliced form of AP-2 and to the related transcription factor AP-2 beta.

Gene Name: transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
Synonyms: TFAP2A, Activator protein 2, AP-2, AP-2a, AP2TF, AP-2alpha, BOFS, TFAP2, Transcription factor AP-2, AP-2 transcription factor, AP2-alpha
Target Sequences: NM_003220 NP_003211.1 P05549

Publications (2)

1
Inhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP-2. Zarelli VE, Dawid IB. Proceedings of the National Academy of Sciences of the United States of America. 2013 110:2870-5. (WB, IP; Zebrafish) [Full Text Article] [PubMed:23382213] Related Antibodies: LS-C87212.
2
Dual control of pcdh8l/PCNS expression and function in Xenopus laevis neural crest cells by adam13/33 via the transcription factors tfap2a and arid3a. Khedgikar V, Abbruzzese G, Mathavan K, Szydlo H, Cousin H, Alfandari D. eLife. 2017 6: (WB; Human) [Full Text Article] [PubMed:28829038] [PMC:PMC5601995] Related Antibodies: LS-C624.

Filtered by: None
Target
TFAP2A / AP-2 (44)
Reactivity
Human (42)
Mouse (15)
Rat (11)
Bovine (5)
Chicken (1)
Chimpanzee (3)
Dog (6)
Gibbon (3)
Guinea pig (4)
Horse (4)
Monkey (6)
Pig (4)
Sheep (1)
Xenopus (1)
Zebrafish (5)
Application
IHC (16)
IHC-Fr (1)
IHC-P (6)
WB (40)
Flo (6)
DB (2)
ELISA (25)
ICC (1)
IF (3)
IP (1)
Peptide-ELISA (1)
Host
rabbit (26)
mouse (16)
goat (2)
Isotype
IgG (18)
IgG1 (7)
IgG1,k (8)
Clonality
monoclonal mc (16)
polyclonal pc (28)
Clone
1A10C5 (1)
2G5 (1)
2H9B5 (1)
2H9F12 (1)
7D2B5 (1)
959C2a (2)
A6/2/2 (1)
Format
AP Conjugated (2)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (4)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (2)
Unconjugated (26)
Epitope
aa407-436 (8)
C-Terminus (5)
N-Terminus (4)
Lys431 (1)
aa1-166 (1)
aa100-150 (1)
aa134-166 (1)
aa214-672 (1)
aa3-14 (1)
aa405-419 (1)
Publications
No (42)
Yes (2)
Showing 1-25 of 44 results

IHC-plus™ TFAP2A / AP-2 Antibody (aa3-14) LS-B427
Goat Polyclonal to Human TFAP2A / AP-2
Chicken, Mouse, Dog, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg 1mg/ml  $485.00
Anti-TFAP2A / AP2 Alpha antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-AP2A Antibody - Western Blot. Western blot of Affinity Purified anti-AP2A antibody shows detection of a band just below 100 kD corresponding to Human AP2A1 in a various preparations. Lane 1 - HeLa nuclear extract, Lane 2 - HeLa, Lane 3 - 293, Lane 4 - A431 and Lane 5 - Jurkat whole cell lysates. In lanes 6-10 the antibody was preincubated with 1 ug/ml of the immunizing peptide which effectively blocks the specific reactivity of this antibody with AP2A. Approximately 20 ug of each lysate was run on a SDS-PAGE and transferred onto nitrocellulose followed by reaction with a 1:500 dilution of anti-AP2A antibody. Detection occurred using a 1:5000 dilution of HRP-labeled Rabbit anti-Goat IgG for 1 hour at room temperature. A chemiluminescence system was used for signal detection (Roche) using a 60-sec exposure time.

TFAP2A / AP-2 Antibody (aa405-419) LS-C87212
Publications (1)
Publications (1)
Goat Polyclonal to Zebrafish TFAP2A / AP-2
Zebrafish
Peptide-ELISA
Unconjugated
100µg 0.5mg/ml  $335.00

TFAP2A / AP-2 Antibody (aa100-150) LS-C624
Publications (1)
Publications (1)
Rabbit Polyclonal (IgG) to Human TFAP2A / AP-2
Xenopus, Rat, Mouse, Dog, Sheep, Bovine, Human, Monkey
WB
Unconjugated
100µg 200µl 0.5mg/ml  $335.00
Western blot of AP-2 in MCF-7 cell lysate with antibody. A protein band of an approximate molecular weight of 55 kD is detected.

IHC-plus™ TFAP2A / AP-2 Antibody (clone 2G5) LS-B6155
Mouse Monoclonal [clone 2G5] (IgG1,k) to Human TFAP2A / AP-2
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg  $495.00
Anti-TFAP2A / AP2 Alpha antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Western blot of TFAP2A expression in transfected 293T cell line by TFAP2A monoclonal antibody.

TFAP2A / AP-2 Antibody (clone 2H9B5) LS-C682429
Mouse Monoclonal [clone 2H9B5] (IgG1) to Human TFAP2A / AP-2
Human
ELISA, Flo, ICC, IHC, WB
Unconjugated
100µl  $365.00
Immunofluorescence analysis of Hela cells using TFAP2A mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher
Immunofluorescence analysis of Hela cells using TFAP2A mouse mAb. Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

TFAP2A / AP-2 Antibody LS-C800564
Rabbit Polyclonal (IgG) to Human TFAP2A / AP-2
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Immunofluorescence Image

TFAP2A / AP-2 Antibody LS-C801427
Rabbit Polyclonal (IgG) to Human TFAP2A / AP-2
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Immunofluorescence Image

TFAP2A / AP-2 Antibody (clone 2H9F12) LS-C682430
Mouse Monoclonal [clone 2H9F12] (IgG1) to Human TFAP2A / AP-2
Human
ELISA, Flo, WB
Unconjugated
100µl  $365.00
Western blot analysis using TFAP2A mAb against HEK293 (1) and TFAP2A (AA: 105-211)-hIgGFc transfected HEK293 (2) cell lysate.
Western blot analysis using TFAP2A mouse mAb against Hela (1), PANC-1 (2), HEK293 (3), and RAW267.4 (4) cell lysate.

TFAP2A / AP-2 Antibody LS-C20684
Mouse Monoclonal (IgG1,k) to Human TFAP2A / AP-2
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100µg  $635.00

TFAP2A / AP-2 Antibody (HRP) LS-C543509
Mouse Monoclonal (IgG1,k) to Human TFAP2A / AP-2
Human
ELISA, IHC, WB
HRP Conjugated
100µl  $755.00

TFAP2A / AP-2 Antibody (Biotin) LS-C523380
Mouse Monoclonal (IgG1,k) to Human TFAP2A / AP-2
Human
ELISA, IHC, WB
Biotin Conjugated
100µl  $755.00

TFAP2A / AP-2 Antibody (FITC) LS-C533420
Mouse Monoclonal (IgG1,k) to Human TFAP2A / AP-2
Human
ELISA, IHC, WB
FITC Conjugated
100µl  $755.00

TFAP2A / AP-2 Antibody (APC) LS-C515112
Mouse Monoclonal (IgG1,k) to Human TFAP2A / AP-2
Human
ELISA, IHC, WB
APC Conjugated
100µl  $755.00

TFAP2A / AP-2 Antibody (AP) LS-C505451
Mouse Monoclonal (IgG1,k) to Human TFAP2A / AP-2
Human
ELISA, IHC, WB
AP Conjugated
100µl  $755.00

TFAP2A / AP-2 Antibody (PE) LS-C651618
Mouse Monoclonal (IgG1,k) to Human TFAP2A / AP-2
Human
ELISA, IHC, WB
PE Conjugated
100µl  $755.00

TFAP2A / AP-2 Antibody (C-Terminus, clone A6/2/2) LS-C122492
Mouse Monoclonal [clone A6/2/2] (IgG) to Human TFAP2A / AP-2
Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100µg  $950.00

TFAP2A / AP-2 Antibody LS-C34990
Rabbit Polyclonal to Human TFAP2A / AP-2
Mouse, Rat, Human, Monkey
ELISA, IHC, IHC-P, IP, WB
Unconjugated
100µl  $530.00

TFAP2A / AP-2 Antibody (aa214-672) LS-C69071
Rabbit Polyclonal (IgG) to Human TFAP2A / AP-2
Human
ELISA, IHC, WB
Unconjugated
100µl  $740.00

TFAP2A / AP-2 Antibody (clone 959C2a) LS-C184321
Mouse Monoclonal [clone 959C2a] (IgG1) to Human TFAP2A / AP-2
Mouse, Human
DB, Flo, WB
Unconjugated
50µg  $325.00
Western blot of immunized recombinant protein using TFAP2A antibody.

TFAP2A / AP-2 Antibody (clone 959C2a) LS-C342377
Mouse Monoclonal [clone 959C2a] (IgG1) to Human TFAP2A / AP-2
Mouse, Human
DB, Flo, WB
Unconjugated
100µg 100µg/ml  $415.00
Detection of TFAP2A by Western blot. Samples: Whole cell lysate from human HEK293 (H, 50 ug) and mouse NIH3T3 (M, 50 ug) cells. Predicted molecular weight: 48 kDa
Western blot analysis of immunized recombinant protein, using anti-TFAP2A monoclonal antibody.

TFAP2A / AP-2 Antibody (clone 1A10C5) LS-C669248
Mouse Monoclonal [clone 1A10C5] (IgG1) to Human TFAP2A / AP-2
Human
ELISA, Flo
Unconjugated
0.1mg  $365.00

TFAP2A / AP-2 Antibody (clone 7D2B5) LS-C669267
Mouse Monoclonal [clone 7D2B5] (IgG1) to Human TFAP2A / AP-2
Human
ELISA, Flo
Unconjugated
0.1mg  $365.00

TFAP2A / AP-2 Antibody (Lys431) LS-C175920
Rabbit Polyclonal to Human TFAP2A / AP-2
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100µl  $345.00
IHC of AP-2/ (K431) pAb in paraffin-embedded human lung carcinoma tissue.
Western blot of AP-2/ (K431) pAb in extracts from HEK293A cells.

TFAP2A / AP-2 Antibody (aa407-436) LS-C328927
Rabbit Polyclonal (IgG) to Human TFAP2A / AP-2
Human
ELISA, WB
Unconjugated
200µl  $590.00

TFAP2A / AP-2 Antibody (aa407-436, APC) LS-C283679
Rabbit Polyclonal (IgG) to Human TFAP2A / AP-2
Human
ELISA, WB
APC Conjugated
200µl  $740.00
Showing 1-25 of 44 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).