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TET3

Tet Methylcytosine Dioxygenase 3

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.

Gene Name: Tet Methylcytosine Dioxygenase 3
Synonyms: TET3, HCG_40738, KIAA0401
Target Sequences: NP_659430.1 O43151

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Products
Antibodies (31)
Primary (31)
TET3 (31)
Human (31)
Mouse (4)
Rat (2)
IHC (11)
IHC-P (8)
WB (24)
ELISA (7)
ICC (1)
IF (5)
Peptide-ELISA (1)
rabbit (13)
mouse (18)
Product Group
IHCPlus (2)
IgG (11)
IgG1 (14)
IgG2a (2)
IgG2b (2)
monoclonal mc (18)
polyclonal pc (13)
1.10E+12 (1)
11E11 (1)
OTI10G4 (2)
OTI11H8 (2)
OTI15H3 (2)
OTI2F10 (2)
OTI3B3 (2)
OTI3G10 (2)
OTI4B7 (2)
OTI5A4 (2)
Biotin Conjugated (1)
Carrier-free (9)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (28)
aa241-568 (18)
aa1-160 (2)
No (31)
TET3 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TET3 Mouse anti-Human Monoclonal (aa241-568) (11E11) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$440
TET3 Antibody - Anti-TET3 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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TET3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
TET3 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-TET3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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TET3 Mouse anti-Human Monoclonal (aa241-568) (OTI3G10) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
TET3 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-TET3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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TET3 Mouse anti-Human Monoclonal (aa241-568) (Carrier-free) (OTI3G10) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
TET3 Antibody - Immunofluorescence analysis of A549 cells.
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TET3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389
TET3 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
TET3 Mouse anti-Human Monoclonal (aa241-568) (Carrier-free) (1.10E+12) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
TET3 Antibody - IHC of paraffin-embedded Human tonsil using anti-TET3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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TET3 Mouse anti-Human Monoclonal (aa241-568) (OTI4B7) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
TET3 Antibody - IHC of paraffin-embedded Human tonsil using anti-TET3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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TET3 Mouse anti-Human Monoclonal (aa241-568) (Carrier-free) (OTI4B7) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
TET3 Antibody - Immunofluorescence staining of TET3 in MCF7 cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human TET3 polyclonal antibody (dilution ratio 1:200) at 4°C overnight. Then cells were stained with the Alexa Fluor 488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to Nucleus.
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TET3 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF
Unconjugated
100 µl/$412
TET3 Antibody - Immunohistochemistry of paraffin-embedded human liver tissue using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TET3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
TET3 Antibody - Immunohistochemistry of paraffin-embedded human liver tissue using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TET3 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, IHC-P
HRP Conjugated
50 µg/$294; 100 µg/$360
TET3 Antibody - Immunohistochemistry of paraffin-embedded human liver tissue using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TET3 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, IHC-P
Biotin Conjugated
50 µg/$294; 100 µg/$360
TET3 Antibody - Immunohistochemistry of paraffin-embedded human liver tissue using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TET3 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, IHC-P
FITC Conjugated
50 µg/$294; 100 µg/$360
TET3 Antibody - Western Blot of rabbit Anti-TET3 Antibody. Lane 1: CEM nuclear extract. Lane 2: THP-1 nuclear extract. Load: 25 µg per lane. Primary antibody: TET3 antibody at 1:1000 for overnight at 4°C. Secondary antibody: HRP rabbit secondary antibody at 1:5000 for 45 min at RT. Block: 5% BLOTTO overnight at 4°C. Predicted/Observed size: Isoforms of TET3 include 180kDa, 167kDa and 78kDa. Other band(s): nonspecific.
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TET3 Rabbit anti-Human Polyclonal (aa1-160) Antibody
Human
ELISA, WB
Unconjugated
25 µl/$304
TET3 Antibody - Western Blot of rabbit Anti-TET3 Antibody. Lane 1: CEM nuclear extract. Lane 2: THP-1 nuclear extract. Load: 25 µg per lane. Primary antibody: TET3 antibody at 1:1000 for overnight at 4°C. Secondary antibody: HRP rabbit secondary antibody at 1:5000 for 45 min at RT. Block: 5% BLOTTO overnight at 4°C. Predicted/Observed size: Isoforms of TET3 include 180kDa, 167kDa and 78kDa. Other band(s): nonspecific.
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TET3 Rabbit anti-Human Polyclonal (aa1-160) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$567
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TET3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
TET3 Rabbit anti-Human Polyclonal Antibody
Human
IF
Unconjugated
20 µl/$275; 100 µl/$389
Select
TET3 Rabbit anti-Human Polyclonal Antibody
Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
TET3 Antibody - Human recombinant protein fragment corresponding to amino acids 241-568 of human TET3 (NP_659430) produced in E.coli.
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TET3 Mouse anti-Human Monoclonal (aa241-568) (OTI3B3) Antibody
Human
WB
Unconjugated
100 µl/$434
TET3 Antibody - Human recombinant protein fragment corresponding to amino acids 241-568 of human TET3 (NP_659430) produced in E.coli.
Select
TET3 Mouse anti-Human Monoclonal (aa241-568) (OTI11H8) Antibody
Human
WB
Unconjugated
100 µl/$434
TET3 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TET3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TET3.
Select
TET3 Mouse anti-Human Monoclonal (aa241-568) (OTI2F10) Antibody
Human
WB
Unconjugated
100 µl/$434
TET3 Antibody - Human recombinant protein fragment corresponding to amino acids 241-568 of human TET3 (NP_659430) produced in E.coli.
Select
TET3 Mouse anti-Human Monoclonal (aa241-568) (OTI10G4) Antibody
Human
WB
Unconjugated
100 µl/$434
TET3 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TET3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TET3.
Select
TET3 Mouse anti-Human Monoclonal (aa241-568) (OTI15H3) Antibody
Human
WB
Unconjugated
100 µl/$434
TET3 Antibody - Human recombinant protein fragment corresponding to amino acids 241-568 of human TET3 (NP_659430) produced in E.coli.
Select
TET3 Mouse anti-Human Monoclonal (aa241-568) (OTI5A4) Antibody
Human
WB
Unconjugated
100 µl/$434
TET3 Antibody - Human recombinant protein fragment corresponding to amino acids 241-568 of human TET3 (NP_659430) produced in E.coli.
Select
TET3 Mouse anti-Human Monoclonal (aa241-568) (Carrier-free) (OTI5A4) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
Viewing 1-25 of 31 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).