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TERT / Telomerase

telomerase reverse transcriptase

Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.

Gene Name:	telomerase reverse transcriptase
Synonyms:	TERT, DKCB4, EST2, HEST2, PFBMFT1, Telomerase, TP2, DKCA2, HTRT, TCS1, Telomerase catalytic subunit, TRT
Target Sequences:	AY007685 AAG23289.1 O14746

Publications (14)

Evolving views of telomerase and cancer. Blasco MA, Hahn WC. Trends in cell biology. 2003 13:289-94. [PubMed:12791294]

The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. Masutomi K, Possemato R, Wong JM, Currier JL, Tothova Z, Manola JB, Ganesan S, Lansdorp PM, Collins K, Hahn WC. Proceedings of the National Academy of Sciences of the United States of America. 2005 102:8222-7. (WB; Human) [PubMed:15928077] [PMC:PMC1149439]

Immunodetection of human telomerase reverse-transcriptase (hTERT) re-appraised: nucleolin and telomerase cross paths. Wu YL, Dudognon C, Nguyen E, Hillion J, Pendino F, Tarkanyi I, Aradi J, Lanotte M, Tong JH, Chen GQ, Sgal-Bendirdjian E. Journal of cell science. 2006 119:2797-806. [PubMed:16772337]

Antigenic profiling of glioma cells to generate allogeneic vaccines or dendritic cell-based therapeutics. Zhang JG, Eguchi J, Kruse CA, Gomez GG, Fakhrai H, Schroter S, Ma W, Hoa N, Minev B, Delgado C, Wepsic HT, Okada H, Jadus MR. Clinical cancer research : an official journal of the American Association for Cancer Research. 2007 13:566-75. (ICC, Flo; Human) [PubMed:17255279]

Quantitation of HER2 and telomerase biomarkers in solid tumors with IgY antibodies and nanocrystal detection. Xiao Y, Gao X, Gannot G, Emmert-Buck MR, Srivastava S, Wagner PD, Amos MD, Barker PE. International journal of cancer. Journal international du cancer. 2008 122:2178-86. [PubMed:18214859]

Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress. Ahmed S, Passos JF, Birket MJ, Beckmann T, Brings S, Peters H, Birch-Machin MA, von Zglinicki T, Saretzki G. Journal of cell science. 2008 121:1046-53. [PubMed:18334557]

Quantitative nuclear proteomics identifies mTOR regulation of DNA damage response. Bandhakavi S, Kim YM, Ro SH, Xie H, Onsongo G, Jun CB, Kim DH, Griffin TJ. Molecular & cellular proteomics : MCP. 2010 9:403-14. (WB; Human) [PubMed:19955088] [PMC:PMC2830849]

EGFR overexpression induces activation of telomerase via PI3K/AKT-mediated phosphorylation and transcriptional regulation through Hif1-alpha in a cellular model of oral-esophageal carcinogenesis. Heeg S, Hirt N, Queisser A, Schmieg H, Thaler M, Kunert H, Quante M, Goessel G, von Werder A, Harder J, Beijersbergen R, Blum HE, Nakagawa H, Opitz OG. Cancer science. 2011 102:351-60. (WB; Human) [PubMed:21156006]

A functional tandem-repeats polymorphism in the downstream of TERT is associated with the risk of nasopharyngeal carcinoma in Chinese population. Zhang Y, Zhang H, Zhai Y, Wang Z, Ma F, Wang H, Li P, Zhang Y, Yu L, Cui Y, He F, Zhou G. BMC medicine. 2011 20:106. (ICC, IHC-P; Human) [PubMed:21929825] [PMC:PMC3191471]

Common variations in TERT-CLPTM1L locus are reproducibly associated with the risk of nasopharyngeal carcinoma in Chinese populations. Zhang Y, Zhang X, Zhang H, Zhai Y, Wang Z, Li P, Yu L, Xia X, Zhang Y, Zeng Y, He F, Zhou G. Oncotarget. 2016 7:759-70. (ICC; Human) [Full Text Article] [PubMed:26621837] [PMC:PMC4808031]

Molecular mechanisms by which oxidative DNA damage promotes telomerase activity. Lee HT, Bose A, Lee CY, Opresko PL, Myong S. Nucleic acids research. 2017 November;45:11752-11765. (Human) [Full Text Article] [PubMed:28981887] [PMC:PMC5714237] Related Antibodies: LS-B95.

Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the mouse ovary. Akino N, Wada-Hiraike O, Isono W, Terao H, Honjo H, Miyamoto Y, Tanikawa M, Sone K, Hirano M, Harada M, Hirata T, Hirota Y, Koga K, Oda K, Fujii T, Osuga Y. Reproductive biology and endocrinology : RB&E. 2019 February;17:23. [Full Text Article] [PubMed:30760288] [PMC:PMC6375213]

MicroRNA-22 enhances radiosensitivity in cervical cancer cell lines via direct inhibition of c-Myc binding protein, and the subsequent reduction in hTERT expression. Mayumi Nakamura, Masami Hayashi, Hiromi Konishi, Misa Nunode, Keisuke Ashihara, Hiroshi Sasaki, Yoshito Terai, Masahide Ohmichi. Oncology letters. 2020 Mar;19:2213-2222. [Full Text Article] [PubMed:32194719] [PMC:PMC7038919] Related Antibodies: LS-B11086.

Position-Dependent Effect of Guanine Base Damage and Mutations on Telomeric G-Quadruplex and Telomerase Extension. Hui-Ting Lee, Samantha Sanford, Tapas Paul, Joshua Choe, Arindam Bose, Patricia L Opresko, Sua Myong. Biochemistry. 2020 July;59:2627-2639. [Full Text Article] [PubMed:32578995] [PMC:PMC8674823] Related Antibodies: LS-B95.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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