TDP1

tyrosyl-DNA phosphodiesterase 1

DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.

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Products

Proteins (11)

Type

Over-Expression Lysate (4)

Recombinant (7)

Target

TDP1 (11)

Publications

No (11)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His-GST, N-terminus (1)

Myc-DDK (Flag) (6)

Species

Human (7)

Mouse (1)

Rat (1)

Source

293T Cells (2)

E. coli (3)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (4)

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TDP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G111838

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.2 kDa

Price:

100 µg/$494

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TDP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121874

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.2 kDa

Price:

100 µg/$494

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Human TDP1 Protein (Recombinant His) - LS-G2164

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human TDP1 Protein (Recombinant GST, N-terminus) (aa121-218) - LS-G62751

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TDP1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71914

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.2 kDa

Price:

20 µg/$1,107

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Human TDP1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71915

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.2 kDa

Price:

20 µg/$1,107

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Human TDP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90927

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.2 kDa

Price:

20 µg/$150

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Human TDP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90928

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.2 kDa

Price:

20 µg/$150

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Rat TDP1 Protein (Recombinant His-GST, N-terminus) (Met1-Leu271) - LS-G133264

Source:

E. coli

Tag:

His-GST, N-terminus

Molecular Weight:

60.4kDa

Price:

10 µg/$265; 50 µg/$347; 200 µg/$682; 100 µg/$545; 1 mg/$1,690; 500 µg/$1,270; 5 mg/$2,637; 2 mg/$1,866

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Mouse TDP1 Protein (Recombinant) (Glu4-Gln215) - LS-G133716

Source:

E. coli

Tag:

None

Molecular Weight:

53.7kDa

Price:

10 µg/$263; 50 µg/$343; 200 µg/$662; 100 µg/$530; 1 mg/$1,657; 500 µg/$1,242; 5 mg/$2,600; 2 mg/$1,832

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Human TDP1 Protein (Recombinant GST) (Full Length) - LS-G34428

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

92.62 kDa

Price:

10 µg/$479; 25 µg/$670

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