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TDP-43 / TARDBP

TAR DNA binding protein

DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.

Gene Name: TAR DNA binding protein
Synonyms: TARDBP, ALS10, TAR DNA-binding protein-43, TDP-43, TAR DNA binding protein, TAR DNA-binding protein 43, TDP43
Target Sequences: NM_007375 NP_031401.1 Q13148

Publications (4)

1
Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis. Geser F, Brandmeir NJ, Kwong LK, Martinez-Lage M, Elman L, McCluskey L, Xie SX, Lee VM, Trojanowski JQ. Archives of neurology. 2008 65:636-41. [PubMed:18474740]
2
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration. Wegorzewska I, Bell S, Cairns NJ, Miller TM, Baloh RH. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:18809-14. [PubMed:19833869] [PMC:PMC2762420]
3
Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients. Mitne-Neto M, Machado-Costa M, Marchetto MC, Bengtson MH, Joazeiro CA, Tsuda H, Bellen HJ, Silva HC, Oliveira AS, Lazar M, Muotri AR, Zatz M. Human molecular genetics. 2011 20:3642-52. [PubMed:21685205] [PMC:PMC3159551]
4
TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes. Kawahara Y, Mieda-Sato A. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:3347-52. [PubMed:22323604] [PMC:PMC3295278]
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Products
Proteins (13)
Over-Expression Lysate (2)
Recombinant (11)
TDP-43 / TARDBP (13)
No (13)
6His, N-terminus (1)
DDK,C-terminus (1)
GST (1)
GST, N-terminus (2)
His (2)
His, N-Terminal (2)
His-SUMO (1)
Myc-DDK (Flag) (3)
Human (11)
Mouse (1)
293T Cells (1)
E. coli (6)
HEK 293 Cells (2)
Sf9 Cells (1)
Wheat Germ Extract (2)
Yeast (1)
Purified (5)
TDP-43 / TARDBP Protein
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E. coli
His
49 kDa
100 µg/$361; 20 µg/$261
TDP-43 / TARDBP Protein
Select
E. coli
His
20 µg/$361; 100 µg/$739; 4 µg/$261
TDP-43 / TARDBP Protein - Recombinant Tar DNA Binding Protein 43kDa By SDS-PAGE
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E. coli
His, N-Terminal
19.8 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
TDP-43 / TARDBP Protein - Recombinant Tar DNA Binding Protein 43kDa By SDS-PAGE
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E. coli
His, N-Terminal
19.7 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
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E. coli
His-SUMO
58.89 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
TDP-43 / TARDBP Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
100 µg/$446; 20 µg/$336; 1 mg/$1,460
TDP-43 / TARDBP Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
GST, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
TDP-43 / TARDBP Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
TDP-43 / TARDBP Protein - 12.5% SDS-PAGE of human TARDBP stained with Coomassie Blue
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Wheat Germ Extract
GST
71.1 kDa
2 µg/$439
TDP-43 / TARDBP Protein
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Sf9 Cells
DDK,C-terminus
45 kDa
20 µg/$677
TDP-43 / TARDBP Protein - Purified recombinant protein TARDBP was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
44.6 kDa
20 µg/$1,107
TDP-43 / TARDBP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
44.6 kDa
20 µg/$150
TDP-43 / TARDBP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
44.6 kDa
100 µg/$494
Viewing 1-13 of 13 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).