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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TDO2

tryptophan 2,3-dioxygenase

TDO2 is a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.

Gene Name: tryptophan 2,3-dioxygenase
Synonyms: TDO2, TDO, TO, TRPO, Tryptophan pyrrolase, Tryptophan oxygenase, Tryptophan 2,3-dioxygenase, Tryptophanase, Tryptamin 2,3-dioxygenase
Target Sequences: NM_005651 NP_005642.1 P48775

Publications (2)

1
Prognostic Significance of Tryptophan Catabolism in Adult T-cell Leukemia/Lymphoma. Masaki A, Ishida T, Maeda Y, Suzuki S, Ito A, Takino H, Ogura H, Totani H, Yoshida T, Kinoshita S, Narita T, Ri M, Kusumoto S, Inagaki A, Komatsu H, Niimi A, Ueda R, Utsunomiya A, Inagaki H, Iida S. Clinical cancer research : an official journal of the American Association for Cancer Research. 2015 21:2830-9. (IHC, IF; Human) [Full Text Article] [PubMed:25788494] Related Antibodies: LS-C174023.
2
The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat. Nagy-Grócz G, Laborc KF, Veres G, Bajtai A, Bohár Z, Zádori D, Fejes-Szabó A, Spekker E, Vécsei L, Párdutz Á. Frontiers in neurology. 2017 8:278. (WB; Rat) [Full Text Article] [PubMed:28659861] [PMC:PMC5469907] Related Antibodies: LS-C111058.

Filtered By: None
Target
TDO2 (24)
Reactivity
Human (24)
Mouse (5)
Rat (4)
Bovine (3)
Chimpanzee (2)
Dog (7)
Gibbon (5)
Guinea pig (3)
Monkey (7)
Pig (3)
Rabbit (3)
Xenopus (3)
Application
IHC (7)
IHC-P (6)
WB (23)
Flo (1)
ELISA (10)
Host
rabbit (19)
mouse (5)
Isotype
IgG (14)
IgG1 (3)
IgG2a (1)
IgG2a,k (1)
Clonality
monoclonal mc (5)
polyclonal pc (19)
Clone
1B1 (1)
1C8 (1)
1D1 (1)
2A4 (1)
4G2 (1)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (13)
Epitope
aa1-30 (8)
N-Terminus (4)
aa71-120 (3)
Publications
No (22)
Yes (2)
Showing 1-24 of 24 results

TDO2 Antibody (clone 4G2) IHC-plus™ LS-B10427
Mouse Monoclonal [clone 4G2] (IgG2a) to Human TDO2
Human
IHC IHC-P WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-TDO / TPH2 / TDO2 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-TDO / TPH2 / TDO2 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-TDO / TPH2 / TDO2 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-TDO / TPH2 / TDO2 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

TDO2 Antibody (clone 2A4) LS-C174023
Publications (1)
Publications (1)
Mouse Monoclonal [clone 2A4] (IgG1) to Human TDO2
Human
IHC IHC-P WB
Unconjugated
100µl  $345.00
IHC of paraffin-embedded Human breast tissue using anti-TDO2 mouse monoclonal antibody.
IHC of paraffin-embedded Human colon tissue using anti-TDO2 mouse monoclonal antibody.
IHC of paraffin-embedded Human breast tissue using anti-TDO2 mouse monoclonal antibody.
IHC of paraffin-embedded Human colon tissue using anti-TDO2 mouse monoclonal antibody.

TDO2 Antibody (aa71-120) LS-C111058
Publications (1)
Publications (1)
Rabbit Polyclonal to Human TDO2
Xenopus, Rat, Pig, Rabbit, Mouse, Dog, Guinea pig, Bovine, Human, Monkey
WB
Unconjugated
50µg  $365.00
TDO2 antibody Western blot of Fetal Small Intestine lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
TDO2 antibody Western blot of Fetal Small Intestine lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

TDO2 Antibody (aa71-120, Biotin) LS-C448003
Rabbit Polyclonal to Human TDO2
Xenopus, Rat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Human, Monkey, Chimpanzee, Gibbon
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
TDO2 antibody Western blot of Fetal Small Intestine lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
TDO2 antibody Western blot of Fetal Small Intestine lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

TDO2 Antibody (aa71-120, FITC) LS-C448004
Rabbit Polyclonal to Human TDO2
Xenopus, Rat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Human, Monkey, Chimpanzee, Gibbon
WB
FITC Conjugated
100µl 1mg/ml  $385.00
TDO2 antibody Western blot of Fetal Small Intestine lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
TDO2 antibody Western blot of Fetal Small Intestine lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

TDO2 Antibody (N-Terminus) IHC-plus™ LS-B5791
Rabbit Polyclonal (IgG) to Human TDO2
Dog, Human, Monkey
IHC IHC-P WB
Unconjugated
50µg  $485.00
Anti-TDO2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
TDO2 antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-TDO2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
TDO2 antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

TDO2 Antibody (N-Terminus, HRP) LS-C448002
Rabbit Polyclonal (IgG) to Human TDO2
Dog, Human, Monkey, Gibbon
IHC IHC-P WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
Anti-TDO2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
TDO2 antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-TDO2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
TDO2 antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

TDO2 Antibody (N-Terminus, Biotin) LS-C448000
Rabbit Polyclonal (IgG) to Human TDO2
Dog, Human, Monkey, Gibbon
IHC IHC-P WB
Biotin Conjugated
100µl 1mg/ml  $385.00
Anti-TDO2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
TDO2 antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-TDO2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
TDO2 antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

TDO2 Antibody (N-Terminus, FITC) LS-C448001
Rabbit Polyclonal (IgG) to Human TDO2
Dog, Human, Monkey, Gibbon
IHC IHC-P WB
FITC Conjugated
100µl 1mg/ml  $385.00
Anti-TDO2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
TDO2 antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-TDO2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
TDO2 antibody Western blot of Fetal Heart lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

TDO2 Antibody (clone 1B1) LS-C173912
Mouse Monoclonal [clone 1B1] (IgG1) to Human TDO2
Human
WB
Unconjugated
100µl 1mg/ml  $335.00
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TDO2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TDO2.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TDO2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TDO2.

TDO2 Antibody (aa1-30) LS-C161783
Rabbit Polyclonal to Human TDO2
Human
WB
Unconjugated
400µl  $305.00
TDO2 Antibody western blot of MDA-MB453 cell line lysates (35 ug/lane). The TDO2 antibody detected the TDO2 protein (arrow).
TDO2 Antibody western blot of MDA-MB453 cell line lysates (35 ug/lane). The TDO2 antibody detected the TDO2 protein (arrow).

TDO2 Antibody (clone 1D1) LS-C337711
Mouse Monoclonal [clone 1D1] (IgG1) to Human TDO2
Human
Flo WB
Unconjugated
100µl 1mg/ml  $335.00
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TDO2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TDO2.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TDO2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TDO2.

TDO2 Antibody LS-C334932
Rabbit Polyclonal (IgG) to Human TDO2
Mouse, Human
IHC WB
Unconjugated
50µl  $235.00; 100µl  $295.00; 200µl  $385.00
Immunohistochemistry of paraffin-embedded Human mammary gland tissue.
Western blot analysis of extracts of various cell lines.
Immunohistochemistry of paraffin-embedded Human mammary gland tissue.
Western blot analysis of extracts of various cell lines.

TDO2 Antibody (aa1-30) LS-C330219
Rabbit Polyclonal (IgG) to Human TDO2
Human
ELISA WB
Unconjugated
200µl  $530.00

TDO2 Antibody (aa1-30, Biotin) LS-C271230
Rabbit Polyclonal (IgG) to Human TDO2
Human
ELISA WB
Biotin Conjugated
200µl  $680.00

TDO2 Antibody (aa1-30, FITC) LS-C271231
Rabbit Polyclonal (IgG) to Human TDO2
Human
ELISA WB
FITC Conjugated
200µl  $680.00

TDO2 Antibody (aa1-30, AP) LS-C271228
Rabbit Polyclonal (IgG) to Human TDO2
Human
ELISA WB
AP Conjugated
200µl  $680.00

TDO2 Antibody (aa1-30, APC) LS-C271229
Rabbit Polyclonal (IgG) to Human TDO2
Human
ELISA WB
APC Conjugated
200µl  $680.00

TDO2 Antibody (aa1-30, PE) LS-C271233
Rabbit Polyclonal (IgG) to Human TDO2
Human
ELISA WB
PE Conjugated
200µl  $680.00

TDO2 Antibody (aa1-30, Azide-free, HRP) LS-C271232
Rabbit Polyclonal (IgG) to Human TDO2
Human
ELISA WB
HRP Conjugated, Azide-free
200µl  $680.00

TDO2 Antibody LS-C660954
Rabbit Polyclonal (IgG) to Human TDO2
Human
ELISA WB
Unconjugated
100µg  $435.00

TDO2 Antibody LS-C345039
Rabbit Polyclonal to Human TDO2
Human
ELISA WB
Unconjugated
100µg  $325.00
Western blot analysis using anti-TDO (human), pAb at 1:2000 dilution. 1: Human TDO (His-tagged). 2: Human IDO (His-tagged). 3: Mouse IDO (His-tagged). 4: SH-sy5y cell lysate. 5: Unrelated protein (His-tagged) (negative control).
Western blot analysis using anti-TDO (human), pAb at 1:2000 dilution. 1: Human TDO (His-tagged). 2: Human IDO (His-tagged). 3: Mouse IDO (His-tagged). 4: SH-sy5y cell lysate. 5: Unrelated protein (His-tagged) (negative control).

TDO2 Antibody (clone 1C8) LS-C198320
Mouse Monoclonal [clone 1C8] (IgG2a,k) to Human TDO2
Human
ELISA
Unconjugated
100µg  $355.00
Detection limit for recombinant GST tagged TDO2 is approximately 10 ng/ml as a capture antibody.
Detection limit for recombinant GST tagged TDO2 is approximately 10 ng/ml as a capture antibody.

TDO2 Antibody LS-C748245
Rabbit Polyclonal (IgG) to Human TDO2
Mouse, Rat, Human
WB
Unconjugated
50µl  $235.00
Western blot analysis of extracts of various cell lines, using TDO2 antibody at 1:500 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 5s.
Western blot analysis of extracts of various cell lines, using TDO2 antibody at 1:500 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 5s.
Showing 1-24 of 24 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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