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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TCR Alpha + TCR Beta

T Cell Receptor Alpha / T Cell Receptor Beta

T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas.

TCR Alpha + TCR Beta Target Details

Target Name: T Cell Receptor Alpha / T Cell Receptor Beta

Filtered By: None
Target
tcr-alpha-tcr-beta (70)
Reactivity
Human (15)
Mouse (27)
Rat (17)
Chicken (11)
Cynomolgus (2)
Monkey (6)
Primate (3)
Rhesus monkey (1)
Application
IHC (27)
IHC-Fr (26)
IHC-P (8)
WB (3)
Flo (67)
Depl (1)
ELISA (2)
Func (2)
ICC (1)
IF (2)
IP (29)
Host
mouse (44)
hamster (26)
Isotype
IgG (25)
IgG1 (25)
IgG1,k (16)
IgG2 (1)
IgG2a (1)
IgG2b (2)
Clonality
monoclonal mc (70)
Clone
1D4B (1)
H57-597 (21)
IP26 (15)
KJ12-98 (1)
R73 (7)
R73,CC52 (1)
R73-2b (1)
R73-2B (1)
TCR-2 (1)
TCR-3 (1)
Format
AP Conjugated (2)
APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (11)
Cy5 Conjugated (4)
FITC Conjugated (15)
HRP Conjugated (2)
PE (4)
PE Conjugated (11)
PerCP Conjugated (1)
Unconjugated (21)
Publications
No (70)
Showing 1-25 of 70 results

TCR Alpha + TCR Beta Antibody (clone H57-597, PE) LS-C76264
Hamster Monoclonal [clone H57-597] (IgG) to Mouse TCR Alpha + TCR Beta
Mouse
Flo IHC IHC-Fr IHC-P IP
PE Conjugated
100µg 0.1mg/ml  $395.00

TCR Alpha + TCR Beta Antibody (clone H57-597) LS-C34548
Hamster Monoclonal [clone H57-597] (IgG) to Mouse TCR Alpha + TCR Beta
Mouse
Flo IHC IHC-Fr WB
Unconjugated
250µg 1mg/ml  $255.00

TCR Alpha + TCR Beta Antibody (clone H57-597, FITC) LS-C76262
Hamster Monoclonal [clone H57-597] (IgG2) to Mouse TCR Alpha + TCR Beta
Mouse
Flo IHC IHC-Fr IHC-P IP
FITC Conjugated
100µg 0.1mg/ml  $375.00

TCR Alpha + TCR Beta Antibody (clone IP26) LS-C106794
Mouse Monoclonal [clone IP26] (IgG1,k) to Human TCR Alpha + TCR Beta
Human
Flo
Unconjugated
25µg  $195.00; 100µg 0.5mg/ml  $235.00
Staining of normal human peripheral blood cells with 0.5 ug of Purified Mouse IgG1, K isotype control (open histogram) or 0.5 ug of Purified anti-human alphabeta TCR (IP26) (colored histogram) followed by FITC Anti-Mouse IgG. Cells in the lymphocyte gate were used for analysis.
Staining of normal human peripheral blood cells with 0.5 ug of Purified Mouse IgG1, K isotype control (open histogram) or 0.5 ug of Purified anti-human alphabeta TCR (IP26) (colored histogram) followed by FITC Anti-Mouse IgG. Cells in the lymphocyte gate were used for analysis.

TCR Alpha + TCR Beta Antibody (clone IP26, APC) LS-C106993
Mouse Monoclonal [clone IP26] (IgG1,k) to Human TCR Alpha + TCR Beta
Human
Flo
APC Conjugated
25tst  $245.00; 100tst  $355.00
Staining of normal human peripheral blood cells with APC Mouse IgG1, K isotype control (open histogram) or APC anti-human alphabeta TCR (IP26) (colored histogram). Cells in the lymphocyte gate were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Staining of normal human peripheral blood cells with APC Mouse IgG1, K isotype control (open histogram) or APC anti-human alphabeta TCR (IP26) (colored histogram). Cells in the lymphocyte gate were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.

TCR Alpha + TCR Beta Antibody (clone R73) LS-C204314
Mouse Monoclonal [clone R73] (IgG1) to Rat TCR Alpha + TCR Beta
Rat, Primate
Depl Flo Func ICC IHC IHC-Fr IHC-P IP WB
Unconjugated
100µg 1mg/ml  $235.00

TCR Alpha + TCR Beta Antibody (clone 1D4B) LS-C189759
Mouse Monoclonal [clone 1D4B] (IgG1,k) to Rat TCR Alpha + TCR Beta
Rat, Cynomolgus, Rhesus monkey
Flo IF IHC IP
Unconjugated
500µg 0.5mg/ml  $445.00

TCR Alpha + TCR Beta Antibody (clone H57-597) LS-C76259
Hamster Monoclonal [clone H57-597] (IgG) to Mouse TCR Alpha + TCR Beta
Mouse
Flo IHC IHC-Fr IHC-P IP
Unconjugated
500µg 0.5mg/ml  $435.00

TCR Alpha + TCR Beta Antibody (clone H57-597, Azide-free) LS-C76267
Hamster Monoclonal [clone H57-597] (IgG) to Mouse TCR Alpha + TCR Beta
Mouse
Flo IHC IHC-Fr IHC-P IP
Unconjugated, Azide-free
500µg  $485.00

TCR Alpha + TCR Beta Antibody LS-C76268
Mouse Monoclonal (IgG1,k) to Chicken TCR Alpha + TCR Beta
Chicken
Flo IHC IHC-Fr IP
Unconjugated
500µg  $485.00

TCR Alpha + TCR Beta Antibody (clone TCR-2) LS-C188710
Mouse Monoclonal [clone TCR-2] (IgG1) to Chicken TCR Alpha + TCR Beta
Chicken
Flo IHC IHC-Fr IP
Unconjugated
250µg 0.5mg/ml  $465.00

TCR Alpha + TCR Beta Antibody (clone H57-597, Biotin) LS-C62698
Hamster Monoclonal [clone H57-597] (IgG) to Mouse TCR Alpha + TCR Beta
Mouse
Flo IHC IHC-Fr WB
Biotin Conjugated
100µg  $225.00; 300µg  $325.00

TCR Alpha + TCR Beta Antibody (clone R73) LS-C132380
Mouse Monoclonal [clone R73] (IgG1) to Rat TCR Alpha + TCR Beta
Rat, Cynomolgus, Monkey
Flo Func IHC IHC-Fr IP
Unconjugated
500µg  $710.00

TCR Alpha + TCR Beta Antibody (clone H57-597, PE) LS-C76266
Hamster Monoclonal [clone H57-597] (IgG) to Mouse TCR Alpha + TCR Beta
Mouse
Flo IHC IHC-Fr IHC-P IP
PE Conjugated
100µg  $485.00

TCR Alpha + TCR Beta Antibody (clone H57-597, PE, Cy5) LS-C76265
Hamster Monoclonal [clone H57-597] (IgG) to Mouse TCR Alpha + TCR Beta
Mouse
Flo IHC IHC-Fr IHC-P IP
PE, Cy5 Conjugated
100µg  $455.00

TCR Alpha + TCR Beta Antibody (clone H57-597, Biotin) LS-C76263
Hamster Monoclonal [clone H57-597] (IgG) to Mouse TCR Alpha + TCR Beta
Mouse
Flo IHC IHC-Fr IHC-P IP
Biotin Conjugated
500µg  $465.00

TCR Alpha + TCR Beta Antibody (clone KJ12-98) LS-C82378
Mouse Monoclonal [clone KJ12-98] (IgG2a) to Mouse TCR Alpha + TCR Beta
Mouse
ELISA Flo IP
Unconjugated
100µl  $450.00

TCR Alpha + TCR Beta Antibody (Biotin) LS-C76270
Mouse Monoclonal (IgG1,k) to Chicken TCR Alpha + TCR Beta
Chicken
Flo IHC IHC-Fr IP
Biotin Conjugated
500µg  $560.00

TCR Alpha + TCR Beta Antibody (FITC) LS-C76269
Mouse Monoclonal (IgG1,k) to Chicken TCR Alpha + TCR Beta
Chicken
Flo IHC IHC-Fr IP
FITC Conjugated
500µg  $605.00

TCR Alpha + TCR Beta Antibody (PE) LS-C76271
Mouse Monoclonal (IgG1,k) to Chicken TCR Alpha + TCR Beta
Chicken
Flo IHC IHC-Fr IP
PE Conjugated
100µg  $465.00

TCR Alpha + TCR Beta Antibody LS-C76272
Mouse Monoclonal (IgG1,k) to Chicken TCR Alpha + TCR Beta
Chicken
Flo IHC IHC-Fr
Unconjugated
500µg  $485.00

TCR Alpha + TCR Beta Antibody (clone TCR-3) LS-C188711
Mouse Monoclonal [clone TCR-3] (IgG1) to Chicken TCR Alpha + TCR Beta
Chicken
Flo IHC IHC-Fr
Unconjugated
250µg 0.5mg/ml  $475.00

TCR Alpha + TCR Beta Antibody (clone R73-2B) LS-C132382
Mouse Monoclonal [clone R73-2B] (IgG2b) to Rat TCR Alpha + TCR Beta
Rat
Flo IHC IHC-Fr
Unconjugated
1000µl  $845.00

TCR Alpha + TCR Beta Antibody (clone R73) LS-C76261
Mouse Monoclonal [clone R73] (IgG1) to Rat TCR Alpha + TCR Beta
Rat
Flo IHC IHC-Fr
Unconjugated
100µg  $385.00

TCR Alpha + TCR Beta Antibody (clone R73-2b) LS-C202447
Mouse Monoclonal [clone R73-2b] (IgG2b) to Rat TCR Alpha + TCR Beta
Rat
Flo IHC IHC-Fr
Unconjugated
1ml  $605.00
Showing 1-25 of 70 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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