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TCN2 is a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.
Gene Name: | transcobalamin II |
Synonyms: | TCN2, D22S676, D22S750, Macrocytic anemia, TC-2, TC II, TCII, Transcobalamin-2, Vitamin B12-binding protein 2, Transcobalamin II, TC, TC2 |
Target Sequences: | NM_000355 NP_000346.2 P20062 |
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