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Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.
Gene Name: | trichoplein, keratin filament binding |
Synonyms: | TCHP, Mitostatin, TpMs, Protein TCHP, Tumor suppressor protein |
Target Sequences: | NM_032300 NP_115676.1 Q9BT92 |
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