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Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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TCF7L2 / TCG4
transcription factor 7-like 2 (T-cell specific, HMG-box)
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
| Gene Name: | transcription factor 7-like 2 (T-cell specific, HMG-box) |
| Family/Subfamily: | Transcription factor , not assigned-Transcription factor |
| Synonyms: | TCF7L2, HMG box transcription factor 4, HTCF-4, T-cell factor-4 variant X2, T-cell factor 4, Transcription factor 7-like 2, TCF-4 |
| Target Sequences: | NM_030756 NP_110383.2 Q9NQB0 |
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