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TCEB3 / Elongin A is the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.
Gene Name: | transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) |
Synonyms: | TCEB3, EloA, Elongin 110 kDa subunit, SIII, TCEB3A, Elongin A, Elongin-A, SIII p110 |
Target Sequences: | NM_003198 NP_003189.2 Q14241 |
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