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T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia.
Gene Name: | T-box 6 |
Synonyms: | TBX6, T-box protein 6, T-box 6, DFNB67 |
Target Sequences: | NM_004608 NP_004599.2 O95947 |
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