ITGA5/Integrin Alpha 5/CD49e belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 and integrin alpha V chains are produced by distinct genes.
|Gene Name:||integrin, alpha 5 (fibronectin receptor, alpha polypeptide)|
|Family/Subfamily:||Integrin , not assigned-Integrin|
|Synonyms:||ITGA5, FNRA, Integrin alpha-5, Integrin Alpha 5, Integrin alpha-F, VLA-5, CD49e, CD49e antigen, VLA5A|
|Target Sequences:||NM_002205 NP_002196.2 P08648|
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