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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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ADD3

adducin 3 (gamma)

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known.

Gene Name: adducin 3 (gamma)
Synonyms: ADD3, ADDL, Adducin-like protein 70, Adducin 3 (gamma), Adducin gamma subunit, Gamma-adducin
Target Sequences: NM_016824 NP_058432.1 Q9UEY8


ADD3 Antibody - Anti-ADD3 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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Rabbit Polyclonal (IgG) to Human ADD3
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $425.00
ADD3 Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human ADD3
Human
IF, IHC, IHC-P, WB
Unconjugated
100µl   $485.00
ADD3 Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human ADD3
Zebrafish, Mouse, Dog, Bovine, Rat, Human, Chimpanzee, Orangutan, Gibbon
IF, IHC, IHC-P, WB
HRP Conjugated
100µl   0.65mg/ml   $405.00
ADD3 Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human ADD3
Zebrafish, Mouse, Dog, Bovine, Rat, Human, Chimpanzee, Orangutan, Gibbon
IF, IHC, IHC-P, WB
Biotin Conjugated
100µl   1mg/ml   $405.00
ADD3 Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human ADD3
Zebrafish, Mouse, Dog, Bovine, Rat, Human, Chimpanzee, Orangutan, Gibbon
IF, IHC, IHC-P, WB
FITC Conjugated
100µl   1mg/ml   $405.00
ADD3 Antibody - Western blot of Adducin gamma antibody
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Rabbit Polyclonal (IgG) to Human ADD3
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
ADD3 Antibody - Staining HepG2 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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Rabbit Polyclonal (IgG) to Human ADD3
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
ADD3 Antibody - Western blot of Adducin (P452) pAb in extracts from A549 cells.
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Rabbit Polyclonal to Human ADD3
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
100µl   $345.00
ADD3 Antibody - Western blot analysis of Gamma-adducin expression in HeLa (A); NIH3T3 (B); H9C2 (C); A375 (D); K562 (E) whole cell lysates.
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Rabbit Polyclonal to Human ADD3
Mouse, Bovine, Rat, Human
ICC, IHC, WB
Unconjugated
100µl   1mg/ml   $245.00
Select
Rabbit Polyclonal (IgG) to Human ADD3
Human
ELISA, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human ADD3
Human
ELISA, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human ADD3
Human
ELISA, WB
FITC Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human ADD3
Human
ELISA, WB
PE Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human ADD3
Human
ELISA, WB
HRP Conjugated, Azide-free
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human ADD3
Human
ELISA, WB
AP Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human ADD3
Human
ELISA, WB
APC Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human ADD3
Human
ELISA, WB
Unconjugated
100µg   $375.00
ADD3 Antibody - Western blot analysis of extracts from HepG2 cells and 293 cells, using ADD3 antibody.
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Rabbit Polyclonal (IgG) to Human ADD3
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µg   $305.00
Select
Rabbit Polyclonal (IgG) to Human ADD3
Human
IP, WB
Unconjugated
100µl   1mg/ml   $405.00
Select
Rabbit Polyclonal (IgG) to Human ADD3
Human
IP, WB
Unconjugated
100µl   1mg/ml   $405.00
ADD3 Antibody - Western blot analysis of the lysates from HT-29 cells using ADD3 antibody.
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Rabbit Polyclonal (IgG) to Human ADD3
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
ADD3 Antibody - ADD3 antibody Western blot of THP-1 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human ADD3
Xenopus, Chicken, Zebrafish, Pig, Horse, Rat, Hamster, Bat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
ADD3 Antibody - ADD3 antibody Western blot of THP-1 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human ADD3
Xenopus, Chicken, Zebrafish, Pig, Horse, Rat, Hamster, Bat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Orangutan
WB
Biotin Conjugated
100µl   1mg/ml   $385.00
ADD3 Antibody - Anti-Gamma-adducin Antibody at 1:1000 dilution + K562 whole cell lysates Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 79 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Select
Rabbit Polyclonal to Human ADD3
Mouse, Rat, Human
WB
Unconjugated
100µl   $325.00
ADD3 Antibody - ADD3 Antibody western blot of NCI-H292 cell line lysates (35 ug/lane). The ADD3 antibody detected the ADD3 protein (arrow).
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Rabbit Polyclonal to Human ADD3
Human
WB
Unconjugated
400µl   $325.00
Viewing 1-25 of 27 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).