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Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity.
Gene Name: | Josephin Domain Containing 1 |
Synonyms: | JOSD1, DJ508I15.2, JSPH1, Josephin-1, KIAA0063, Josephin domain-containing 1, Josephin domain containing 1 |
Target Sequences: | NM_014876 NP_055691.1 Q15040 |
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