Products
Research Areas
COVID-19
Resources
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us

Locations


Orders Processing,
Shipping & Receiving,
Warehouse

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464


Production Lab

Floor 6, Suite 610/620
20700 44th Avenue W
Lynnwood, WA 98036

Telephone Numbers



Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565

Contact Us



Additional Contact Details

Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

OPRM1 / Mu Opioid Receptor

opioid receptor, mu 1

Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extend to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling whereas morphine induces only low desensitization and endocytosis. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis. Isoform 12 couples to GNAS and is proposed to be involved in excitatory effects. Isoform 16 and isoform 17 do not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity.

Gene Name: opioid receptor, mu 1
Family/Subfamily: GPCR , Opioid
Synonyms: OPRM1, M-OR-1, LMOR, MOR, Mu-type opioid receptor, HMOP, Opioid mu receptor, MOP, MOR-1, MOR1, Mu opioid receptor, Opioid receptor, mu 1, KIAA0403, MOR-1C, Mu opiate receptor, Mu opioid receptor hMOR-1a, Opioid mu-type receptor, OPRM
Target Sequences: NM_000914 CAI20458.1 P35372

Publications (2)

1
Endogenous opioids facilitate intrinsically-rewarded birdsong. Sharon A Stevenson, Alice Piepenburg, Jeremy A Spool, Caroline S Angyal, Allison H Hahn, Changjiu Zhao, Lauren V Riters. Scientific reports. 2020 July;10:11083. [Full Text Article] [PubMed:32632172] [PMC:PMC7338348]
2
The Involvement of the Endogenous Opioid System in the Gastrointestinal Aging in Mice and Humans. Agata Szymaszkiewicz, Marcin Talar, Jakub Wlodarczyk, Mikolaj Swierczynski, Adrian Bartoszek, Julia Krajewska, Anna Mokrowiecka, Ewa Malecka-Wojciesko, Jakub Fichna, Marta Zielinska. International journal of molecular sciences. 2022 March;23: [Full Text Article] [PubMed:35408926] [PMC:PMC8998735]

☰ Filters
Antibodies (41)
Proteins (15)
ELISA Kits (9)
Cell-Based (1)
Custom (2)
Over-Expression Lysate (12)
Primary (41)
Recombinant (3)
Sandwich (6)
OPRM1 / Mu Opioid Receptor (65)
Human (42)
Mouse (27)
Rat (17)
Bat (1)
Bovine (5)
Chimpanzee (3)
Dog (4)
Guinea pig (3)
Hamster (1)
Horse (3)
Monkey (4)
Pig (6)
Rabbit (3)
IHC (24)
IHC-P (10)
WB (32)
Flo (6)
ELISA (15)
ICC (2)
IP (1)
Peptide-ELISA (4)
rabbit (39)
mouse (1)
rabbit-new zealand white (1)
Product Group
GPCR Database Antibodies (3)
IHCPlus (1)
PathPlus Neuro (3)
IgG (27)
IgG2a (1)
monoclonal mc (1)
polyclonal pc (40)
12K148 (1)
12 x 8-Well Microstrips (1)
96-Well Microplate (1)
96-Well Strip Plate (7)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (30)
aa161-187 (7)
C-Terminus (5)
aa251-300 (4)
N-Terminus (2)
pSer375 (2)
40-120 aa, N-terminal (1)
Extracellular Domain (1)
Ser375 (1)
Ser57 (1)
aa21-70 (1)
aa341-390 (1)
aa370-395 (1)
aa385-398 (1)
aa8-57 (1)
p375 (1)
pSer377 (1)
No (63)
Yes (2)
Adherent Cell Cultures (1)
Cell Lysates (1)
Plasma (5)
Serum (5)
Tissue Homogenates (2)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (13)
Human (9)
293T Cells (6)
HEK 293 Cells (7)
Wheat Germ Extract (2)
Purified (1)
OPRM1 / Mu Opioid Receptor Antibody - Anti-OPRM1 / Mu Opioid Receptor antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Neuroscience
Fast Shipping
OPRM1 / Mu Opioid Receptor Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Dog, Bovine, Hamster, Pig, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
OPRM1 / Mu Opioid Receptor Antibody - Anti-OPRM1 / Mu Opioid Receptor antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Neuroscience
Fast Shipping
OPRM1 / Mu Opioid Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
Select
OPRM1 / Mu Opioid Receptor Rabbit anti-Human Polyclonal (pSer377) Antibody
Mouse, Human
IP, WB
Unconjugated
100 µl/$689
OPRM1 / Mu Opioid Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
OPRM1 / Mu Opioid Receptor Antibody - OPRM1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Select
OPRM1 / Mu Opioid Receptor Rabbit anti-Human Polyclonal (aa161-187) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
OPRM1 / Mu Opioid Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
OPRM1 / Mu Opioid Receptor Antibody - Anti-OPRM1 / Mu Opioid Receptor antibody IHC of human brain, neuron. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Neuroscience
Fast Shipping
OPRM1 / Mu Opioid Receptor Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
OPRM1 / Mu Opioid Receptor Antibody - Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Opioid Receptor Antibody. The picture on the right is blocked with the synthesized peptide.
Select
OPRM1 / Mu Opioid Receptor Rabbit anti-Human Polyclonal (aa341-390) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
OPRM1 / Mu Opioid Receptor Antibody - Immunohistochemistry image at a dilution of 1:500 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Select
OPRM1 / Mu Opioid Receptor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
OPRM1 / Mu Opioid Receptor ELISA Kit
Select
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
OPRM1 / Mu Opioid Receptor Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
OPRM1 / Mu Opioid Receptor Rabbit anti-Human Polyclonal (aa8-57) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
OPRM1 / Mu Opioid Receptor Antibody - Western blot analysis of Mu Opioid Receptor expression in A431 (A); NIH3T3 (B) whole cell lysates.
Select
OPRM1 / Mu Opioid Receptor Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Bovine, Rat, Pig, Human, Monkey
WB
Unconjugated
100 µl/$299
Select
OPRM1 / Mu Opioid Receptor Rabbit anti-Human Polyclonal (aa161-187) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
Select
OPRM1 / Mu Opioid Receptor Rabbit anti-Human Polyclonal (aa161-187) (Biotin) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
Select
OPRM1 / Mu Opioid Receptor Rabbit anti-Human Polyclonal (aa161-187) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
Select
OPRM1 / Mu Opioid Receptor Rabbit anti-Human Polyclonal (aa161-187) (APC) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
Select
OPRM1 / Mu Opioid Receptor Rabbit anti-Human Polyclonal (aa161-187) (PE) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
Select
OPRM1 / Mu Opioid Receptor Rabbit anti-Human Polyclonal (aa161-187) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
OPRM1 / Mu Opioid Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
OPRM1 / Mu Opioid Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
OPRM1 / Mu Opioid Receptor Antibody - Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100 (4°C, overnight). High-pressure and temperature Tris-EDTA, pH8.0 was used for antibody retrieval. Negative control (right) obtained from antibody was pre-absorbed by immunogen peptide.
Select
OPRM1 / Mu Opioid Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
OPRM1 / Mu Opioid Receptor Antibody - Immunohistochemistry analysis of paraffin-embedded human brain tissue, using OPRM1 Antibody. The picture on the right is blocked with the synthesized peptide.
Select
OPRM1 / Mu Opioid Receptor Rabbit anti-Human Polyclonal (aa21-70) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Select
OPRM1 / Mu Opioid Receptor Rabbit anti-Human Polyclonal (40-120 aa, N-terminal) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Select
OPRM1 / Mu Opioid Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Select
OPRM1 / Mu Opioid Receptor Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, ICC, WB
Unconjugated
100 µl/$587
Viewing 1-25 of 65 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).