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This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Gene Name: | islet cell autoantigen 1, 69kDa |
Synonyms: | ICA1, 69 kDa islet cell autoantigen, ICA69, Islet cell autoantigen 1, p69, Islet cell autoantigen p69, ICAp69 |
Target Sequences: | NM_004968 NP_004959.2 Q05084 |
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