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PTRH2 / BIT1

peptidyl-tRNA hydrolase 2

PTRH2 / BIT1 is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is released from the mitochondria into the cytosol, and promotes caspase-independent apoptosis through interactions with transcriptional regulators. This gene has been implicated in the development and progression of tumors, and mutations in this gene have been associated with an infantile multisystem neurologic, endocrine, and pancreatic disease (INMEPD) characterized by intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency (PMID: 25574476). Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Name: peptidyl-tRNA hydrolase 2
Synonyms: PTRH2, BIT1, CGI-147, Peptidyl-tRNA hydrolase 2, PTH 2
Target Sequences: NM_016077 NP_057161.1 Q9Y3E5

☰ Filters
Antibodies (29)
Proteins (5)
Over-Expression Lysate (2)
Primary (29)
Recombinant (3)
PTRH2 / BIT1 (34)
Human (29)
Mouse (8)
Rat (5)
Bovine (3)
Chimpanzee (3)
Dog (3)
Gibbon (3)
Guinea pig (3)
Horse (3)
Monkey (3)
Pig (3)
IHC (13)
IHC-P (2)
WB (29)
ELISA (16)
ICC (2)
IF (6)
Peptide-ELISA (1)
rabbit (29)
Product Group
IHCPlus (1)
IgG (27)
polyclonal pc (29)
APC Conjugated (2)
Azide-free (2)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (2)
Unconjugated (16)
Internal (7)
aa26-55 (7)
aa100-149 (4)
N-Terminus (1)
aa129-179 (1)
aa40-179 (1)
No (34)
GST (1)
His (1)
His,N-terminus (1)
Myc-DDK (Flag) (2)
Human (4)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (1)
PTRH2 / BIT1 Antibody - Anti-PTRH2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PTRH2 / BIT1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$440
PTRH2 / BIT1 Antibody - Immunohistochemistry of paraffin-embedded rat brain tissue.
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PTRH2 / BIT1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
PTRH2 / BIT1 Antibody - Immunofluorescent analysis of PTRH2 staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.
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PTRH2 / BIT1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
PTRH2 / BIT1 Antibody - Immunohistochemistry of Bit1 in human small intestine tissue with Bit1 antibody at 10 ug/ml.
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PTRH2 / BIT1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
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PTRH2 / BIT1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$341
PTRH2 / BIT1 Antibody - Immunohistochemistry of paraffin-embedded human small intestine using antibody at 1:100 dilution.
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PTRH2 / BIT1 Rabbit anti-Human Polyclonal (aa40-179) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
Select
PTRH2 / BIT1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
Select
PTRH2 / BIT1 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
Select
PTRH2 / BIT1 Rabbit anti-Human Polyclonal (Internal) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
Select
PTRH2 / BIT1 Rabbit anti-Human Polyclonal (Internal) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
Select
PTRH2 / BIT1 Rabbit anti-Human Polyclonal (Internal) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
Select
PTRH2 / BIT1 Rabbit anti-Human Polyclonal (Internal) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
Select
PTRH2 / BIT1 Rabbit anti-Human Polyclonal (Internal) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
PTRH2 / BIT1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rat, Human
IHC, WB
Unconjugated
100 µg/$649
Select
PTRH2 / BIT1 Rabbit anti-Human Polyclonal (aa26-55) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
PTRH2 / BIT1 Rabbit anti-Human Polyclonal (aa26-55) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
PTRH2 / BIT1 Rabbit anti-Human Polyclonal (aa26-55) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
PTRH2 / BIT1 Rabbit anti-Human Polyclonal (aa26-55) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
PTRH2 / BIT1 Rabbit anti-Human Polyclonal (aa26-55) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
PTRH2 / BIT1 Rabbit anti-Human Polyclonal (aa26-55) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
PTRH2 / BIT1 Antibody - Western blot analysis of PTRH2 using COLO205 whole cells lysates
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PTRH2 / BIT1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
PTRH2 / BIT1 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Human
WB
Unconjugated
100 µg/$649
Select
PTRH2 / BIT1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
100 µg/$569
PTRH2 / BIT1 Antibody - PTRH2 antibody ARP44695_T100-NP_001015509-PTRH2(peptidyl-tRNA hydrolase 2) Antibody Western blot of Jurkat lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PTRH2 / BIT1 Rabbit anti-Human Polyclonal (aa100-149) Antibody
Human
WB
Unconjugated
100 µl/$397
PTRH2 / BIT1 Antibody - PTRH2 Antibody western blot of MDA-MB231 cell line lysates (35 ug/lane). The PTRH2 antibody detected the PTRH2 protein (arrow).
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PTRH2 / BIT1 Rabbit anti-Human Polyclonal (aa26-55) Antibody
Human
WB
Unconjugated
400 µl/$393
Viewing 1-25 of 34 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).