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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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HUWE1 / ARFBP1

HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation.

Gene Name: HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
Synonyms: HUWE1, ARF-binding protein 1, ARF-BP1, BJ-HCC-24 tumor antigen, Ib772, KIAA0312, LASU1, Mcl-1 ubiquitin ligase E3, HECTH9, MULE, HSPC272, KIAA1578, URE-B1, UREB1, URE-binding protein 1, HECT domain protein LASU1, Large structure of UREB1
Target Sequences: NM_031407 NP_113584.3 Q7Z6Z7

Publications (3)

1
Huwe1 interacts with Gadd45b under oxygen-glucose deprivation and reperfusion injury in primary Rat cortical neuronal cells. He GQ, Xu WM, Li JF, Li SS, Liu B, Tan XD, Li CQ. Molecular brain. 2015 8:88. (WB, IP, IF; Rat) [Full Text Article] [PubMed:26698301] [PMC:PMC4690333] Related Antibodies: LS-B1359.
2
HUWE1 plays important role in mouse preimplantation embryo development and the dysregulation is associated with poor embryo development in humans. Chen LJ, Xu WM, Yang M, Wang K, Chen Y, Huang XJ, Ma QH. Scientific reports. 2016 6:37928. (WB, IF; Mouse) [Full Text Article] [PubMed:27901130] [PMC:PMC5128802] Related Antibodies: LS-B1359.
3
Obesity promotes liver carcinogenesis via Mcl-1 stabilization independent of IL-6R alpha signaling. Gruber S, Straub BK, Ackermann PJ, Wunderlich CM, Mauer J, Seeger JM, B[Character fc]ning H, Heukamp L, Kashkar H, Schirmacher P, Br[Character fc]ning JC, Wunderlich FT. Cell reports. 2013 Aug;4:669-80. [Full Text Article] [PubMed:23954788] Related Antibodies: LS-B1359.

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Viewing 1-9 of 9 items
HUWE1 / ARFBP1 Antibody - Anti-HUWE1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Rabbit Polyclonal (IgG) to Human HUWE1 / ARFBP1
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $425.00
HUWE1 / ARFBP1 Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Goat Polyclonal (IgG) to Human HUWE1 / ARFBP1
Human
IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $425.00
HUWE1 / ARFBP1 Antibody - Detection of Human Lasu1/Ureb1 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-Lasu1/Ureb1 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.
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Rabbit Polyclonal (IgG) to Human HUWE1 / ARFBP1
Human
IHC, IHC-P, IP, WB
Unconjugated
100µl   1mg/ml   $405.00
HUWE1 / ARFBP1 Antibody - Detection of Human Lasu1/Ureb1 by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-Lasu1/Ureb1 used at a dilution of 1:250.
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Rabbit Polyclonal (IgG) to Human HUWE1 / ARFBP1
Human
IHC, IHC-P
Unconjugated
100µl   $415.00
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Rabbit Polyclonal (IgG) to Human HUWE1 / ARFBP1
Human
ELISA, WB
Unconjugated
100µg   $375.00
HUWE1 / ARFBP1 Antibody - Western blot analysis of HUWE1 expression in 293T whole cells lysate. The lane on the left is treated with the antigen-specific peptide.
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Rabbit Polyclonal (IgG) to Human HUWE1 / ARFBP1
Mouse, Human
ELISA, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
HUWE1 / ARFBP1 Antibody - Detection of full length Huwe1 (~482kDa) and its degradation fragments in mouse testis lysate (50ug) by Western blotting using PW0950 at 1:100 dilution.
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Rabbit Polyclonal to Mouse HUWE1 / ARFBP1
Mouse, Rat, Human
WB
Unconjugated
100µl   $475.00
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Rabbit Polyclonal to Human HUWE1 / ARFBP1
Mouse, Human
IHC-P
Unconjugated
100µg   100µl   1mg/ml   $305.00
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Goat Polyclonal to Human HUWE1 / ARFBP1
Xenopus, Bat, Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
Peptide-ELISA
Unconjugated
100µg   0.5mg/ml   $335.00

Viewing 1-9 of 9 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).