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NOG / Noggin

noggin

The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse.

Gene Name: noggin
Synonyms: NOG, Symphalangism 1 (proximal), SYNS1, SYM1, Noggin
Target Sequences: NM_005450 NP_005441.1 Q13253

Publications (2)

1
Self-renewing Monolayer of Primary Colonic or Rectal Epithelial Cells. Wang Y, DiSalvo M, Gunasekara DB, Dutton J, Proctor A, Lebhar MS, Williamson IA, Speer J, Howard RL, Smiddy NM, Bultman SJ, Sims CE, Magness ST, Allbritton NL. Cellular and molecular gastroenterology and hepatology. 2017 March;4:165-182. [Full Text Article] [PubMed:29204504] [PMC:PMC5710741]
2
Juvenile idiopathic arthritis fibroblast-like synoviocytes influence chondrocytes to alter BMP antagonist expression demonstrating an interaction between the two prominent cell types involved in endochondral bone formation. Megan M Simonds, Amanda R Schlefman, Suzanne M McCahan, Kathleen E Sullivan, Carlos D Rose, AnneMarie C Brescia. Pediatric rheumatology online journal. 2020 November;18:89. [Full Text Article] [PubMed:33198759] [PMC:PMC7670793]

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NOG / Noggin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$834
NOG / Noggin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$958
NOG / Noggin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse, Human, Rat
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$854
NOG / Noggin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
NOG / Noggin ELISA Kit
Select
Sandwich
96-Well Microplate
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
NOG / Noggin Antibody - IHC of paraffin-embedded Human lung tissue using anti-Nog mouse monoclonal antibody.
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NOG / Noggin Mouse anti-Human Monoclonal (OTI1H8) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
NOG / Noggin Antibody - IHC of paraffin-embedded Human lung tissue using anti-Nog mouse monoclonal antibody.
Select
NOG / Noggin Mouse anti-Human Monoclonal (aa28-232) (Carrier-free) (OTI1H8) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
Select
NOG / Noggin Rabbit anti-Human Polyclonal (aa84-111) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
Select
NOG / Noggin Rabbit anti-Human Polyclonal (aa84-111) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
NOG / Noggin Antibody - Anti-Nog mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY Nog.
Select
NOG / Noggin Mouse anti-Human Monoclonal (OTI4C12) Antibody
Dog, Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
NOG / Noggin Antibody - Anti-Nog mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY Nog.
Select
NOG / Noggin Mouse anti-Human Monoclonal (aa28-232) (Carrier-free) (OTI4C12) Antibody
Dog, Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
NOG / Noggin Antibody - NOG Antibody western blot of HepG2 cell line lysates (35 ug/lane). The NOG antibody detected the NOG protein (arrow).
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NOG / Noggin Rabbit anti-Human Polyclonal (aa84-111) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$393
NOG / Noggin Protein - Recombinant Noggin By SDS-PAGE
Select
E. coli
His-GST, N-terminus
40.1 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
NOG / Noggin Antibody - Immunohistochemical staining of paraffin-embedded breast using anti-Nog mouse monoclonal antibody.
Select
NOG / Noggin Mouse anti-Human Monoclonal (OTI1C1) Antibody
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
NOG / Noggin Antibody - Immunohistochemical staining of paraffin-embedded breast using anti-Nog mouse monoclonal antibody.
Select
NOG / Noggin Mouse anti-Human Monoclonal (aa28-232) (Carrier-free) (OTI1C1) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
Select
NOG / Noggin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
NOG / Noggin Antibody - Immunohistochemistry of paraffin-embedded human lung tissue at dilution of 1:100
Select
NOG / Noggin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
Select
NOG / Noggin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50 µl/$334; 100 µl/$397
NOG / Noggin Antibody - Immunocytochemistry staining of HeLa cells surface-expressing Noggin-PDGFR transmembrane domain fused protein using Noggin mouse monoclonal antibody (dilution 1:100).
Select
NOG / Noggin Mouse anti-Human Monoclonal Antibody
Human
ICC, WB
Unconjugated
100 µl/$391
NOG / Noggin Antibody - Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200.
Select
NOG / Noggin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
NOG / Noggin Antibody - NOG / Noggin antibody Western blot of ACHN lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NOG / Noggin Rabbit anti-Human Polyclonal (aa71-120) Antibody
Mouse, Human
IHC, WB
Unconjugated
100 µl/$424
NOG / Noggin Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer tissue  using NOG Polyclonal Antibody at dilution of 1:40(×200)
Select
NOG / Noggin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
NOG / Noggin Antibody - Immunohistochemistry of paraffin-embedded Human gastric cancer tissue  using NOG Polyclonal Antibody at dilution of 1:50(×200)
Select
NOG / Noggin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Select
NOG / Noggin Mouse anti-Human Monoclonal (aa28-232) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$680
NOG / Noggin Antibody - Immunocytochemistry staining of HeLa cells surface-expressing Noggin-PDGFR transmembrane domain fused protein using Noggin mouse mAb (dilution 1:100).
Select
NOG / Noggin Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
Viewing 1-25 of 158 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).