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Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex. TIM21 probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.
Gene Name: | translocase of inner mitochondrial membrane 21 homolog (yeast) |
Synonyms: | TIMM21, HSPC154, TIM21, C18orf55 |
Target Sequences: | NM_014177 NP_054896.2 Q9BVV7 |
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