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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
Contact Us
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866-819-4732 (Toll Free North America
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FGFR4

fibroblast growth factor receptor 4

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

Gene Name: fibroblast growth factor receptor 4
Family/Subfamily: Protein Kinase , FGF Receptor
Synonyms: FGFR4, CD334, CD334 antigen, Hydroxyaryl-protein kinase, FGFR-4, JTK2, TKF, Tyrosylprotein kinase, FGF receptor 4, Protein-tyrosine kinase
Target Sequences: NM_002011 NP_002002.3 P22455


FGFR4 Antibody - Anti-FGFR4 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Mouse Monoclonal [clone 53CT32.19.3] (IgG1,k) to Human FGFR4
Human
IHC, IHC-P, WB
Unconjugated
200µl   $425.00
FGFR4 Antibody - Anti-FGFR4 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Select
Mouse Monoclonal [clone 4H2B10B2] (IgG1) to Human FGFR4
Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50µl   1mg/ml   $425.00
FGFR4 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Select
Rabbit Polyclonal to Human FGFR4
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
200µl   $325.00
FGFR4 Antibody - Confocal immunofluorescence of methanol-fixed HEK293 cells transfected with FGFR4-hIgGFc using FGFR4 mouse monoclonal antibody(green), showing membrane localization. Blue: DRAQ5 fluorescent DNA dye.
Select
Mouse Monoclonal [clone 7H1] (IgG1) to Human FGFR4
Human
ELISA, IF, WB
Unconjugated
100µl   $345.00
FGFR4 Antibody - Western blot of Phospho-FGFR-4 (Y642) antibody
Select
Rabbit Polyclonal (IgG) to Human FGFR4
Mouse, Rat, Human
ELISA, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Mouse Monoclonal [clone 4FR6D3] (IgG1) to Human FGFR4
Human
Flo, ICC
Unconjugated
0.1mg   1mg/ml   $255.00
FGFR4 Antibody - Surface staining of CD334 transfectants with anti-CD334 (4FR6D3) PE.
Select
Mouse Monoclonal [clone 4FR6D3] (IgG1) to Human FGFR4
Human
Flo, ICC
PE Conjugated
100tst   $315.00
FGFR4 Antibody - Western blot analysis of FGFR4 expression in HEK293T (A); PC12 (B) whole cell lysates.
Select
Rabbit Polyclonal to Human FGFR4
Rabbit, Mouse, Rat, Human
WB
Unconjugated
100µl   1mg/ml   $245.00
Select
Rabbit Polyclonal (IgG) to Human FGFR4
Human
Flo, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human FGFR4
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200µl   0.35mg/ml   $740.00
Select
Rabbit Polyclonal (IgG) to Human FGFR4
Human
ELISA, Flo, IF, IHC, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human FGFR4
Human
ELISA, Flo, IF, IHC, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human FGFR4
Human
ELISA, Flo, IF, IHC, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human FGFR4
Human
ELISA, Flo, IF, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human FGFR4
Human
ELISA, Flo, IF, IHC, WB
PE Conjugated
200µl   $740.00
FGFR4 Antibody - FGFR4 antibody IHC-paraffin: Human Lung Cancer Tissue.
Select
Rabbit Polyclonal to Human FGFR4
Human
IHC, IHC-P, WB
Unconjugated
100µg   0.5mg/ml   $355.00
Select
Mouse Monoclonal (IgG1) to Human FGFR4
Human
ELISA, WB
FITC Conjugated
200µl   $740.00
Select
Mouse Monoclonal (IgG1,k) to Human FGFR4
Human
ELISA, WB
APC Conjugated
200µl   $740.00
FGFR4 Antibody - Western blot of FGFR4 (arrow) using rabbit polyclonal FGFR4 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FGFR4 gene (Lane 2) (Origene Technologies).
Select
Rabbit Polyclonal to Human FGFR4
Human
WB
Unconjugated
400µl   $325.00
Select
Rabbit Monoclonal [clone 124] (IgG) to Rat FGFR4
Rat
ELISA
Unconjugated, Preservative Free
50µl   $245.00; 100µl   $305.00; 1ml   $1,335.00
FGFR4 Antibody - FGFR4 Antibody in Immunofluorescence (IF)
Select
Mouse Monoclonal [clone 7H1] (IgG1) to Human FGFR4
Human
ICC, IF, WB
Unconjugated
100µl   $445.00
FGFR4 Antibody - Confocal Immunofluorescence (IF) analysis of methanol-fixed HEK293 cells trasfected with FGFR4-hIgGFc using FGFR-4 Monoclonal Antibody (green), showing membrane localization. Blue: DRAQ5 fluorescent DNA dye.
Select
Mouse Monoclonal (IgG1) to Human FGFR4
Human
ELISA, IF, WB
Unconjugated
100µl   $345.00
Select
Mouse Monoclonal (IgG1) to Human FGFR4
Human
ELISA, ICC, WB
Unconjugated
50µl   1mg/ml   $315.00; 100µl   1mg/ml   $375.00; 200µl   1mg/ml   $435.00
FGFR4 Antibody - Immunohistochemistry (IHC) analysis of paraffin-embedded Human Liver Tissues with AEC staining using FGFR-4 Monoclonal Antibody.
Select
Mouse Monoclonal (IgG1) to Human FGFR4
Human
ELISA, IHC, WB
Unconjugated
100µl   $345.00
Select
Rabbit Polyclonal (IgG) to Human FGFR4
Human
ELISA, IHC, WB
Unconjugated
100µg   $375.00
Viewing 1-25 of 76 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).