TAP2

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

TAP2 (6)

Publications

No (6)

Tag

GST (2)

His-T7, N-terminus (2)

Myc-DDK (Flag) (2)

Species

Human (4)

Rat (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

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TAP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G111553

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71.8 kDa

Price:

100 µg/$710

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Human TAP2 Protein (Recombinant GST) (Full Length) - LS-G30622

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

101.2 kDa

Price:

10 µg/$479; 25 µg/$670

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Human TAP2 Protein (Recombinant GST) (Full Length) - LS-G30624

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

102.1 kDa

Price:

2 µg/$439

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Human TAP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74531

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71.8 kDa

Price:

20 µg/$215

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Rat TAP2 Protein (Recombinant His-T7, N-terminus) (Arg467-Ala703) - LS-G133599

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

29.8kDa

Price:

10 µg/$270; 50 µg/$372; 200 µg/$745; 100 µg/$597; 1 mg/$1,791; 500 µg/$1,357; 5 mg/$2,749; 2 mg/$1,972

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Human TAP2 Protein (Recombinant His-T7, N-terminus) (Val468-Leu686) - LS-G133410

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

27.7kDa

Price:

10 µg/$264; 50 µg/$343; 200 µg/$665; 100 µg/$532; 1 mg/$1,662; 500 µg/$1,248; 5 mg/$2,608; 2 mg/$1,838

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