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Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.
| Gene Name: | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) |
| Family/Subfamily: | Transporter , ATP-binding cassette - ABCB/MDR |
| Synonyms: | TAP2, ABC transporter, MHC 2, ABCB3, APT2, Antigen peptide transporter 2, D6S217E, ABC18, Ham2, Peptide supply factor 2, Peptide transporter PSF2, Peptide transporter TAP2, PSF2, Y1, PSF-2, RING11 |
| Target Sequences: | NM_000544 NP_000535.3 Q03519 |
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