TAOK2 / TAO2

TAO kinase 2

Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

TAOK2 / TAO2 (4)

Publications

No (4)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human TAOK2 / TAO2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72431

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

119.1 kDa

Price:

20 µg/$1,107

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Human TAOK2 / TAO2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92413

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

119.1 kDa

Price:

20 µg/$215

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Human TAOK2 / TAO2 Protein (Recombinant GST, N-terminus) (aa831-930) - LS-G61082

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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TAOK2 / TAO2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100387

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

119.1 kDa

Price:

100 µg/$710

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