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Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.
Gene Name: | TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa |
Synonyms: | TAF1C, MGC:39976, SL1, 110kD subunit, TBP-associated factor 1C, TAFI110, Transcription factor SL1, SL1, TAFI95 |
Target Sequences: | NM_005679 NP_005670.3 Q15572 |
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