TAB1

TGF-beta activated kinase 1/MAP3K7 binding protein 1

TAB1 was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

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Products

Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

TAB1 (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

Myc-DDK (Flag) (5)

Species

Human (6)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human TAB1 Protein (Recombinant His, N-Terminal) (aa189-439) - LS-G16162

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

30.6 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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TAB1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105744

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.7 kDa

Price:

100 µg/$710

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TAB1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115509

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.5 kDa

Price:

100 µg/$494

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Human TAB1 Protein (Recombinant GST) (Full Length) - LS-G32158

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

81.18 kDa

Price:

10 µg/$479; 25 µg/$670

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Human TAB1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67090

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.5 kDa

Price:

20 µg/$1,107

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Human TAB1 Protein (Recombinant GST, N-terminus) (aa3-100) - LS-G64574

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TAB1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79097

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.5 kDa

Price:

20 µg/$150

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Human TAB1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79098

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.7 kDa

Price:

20 µg/$215

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