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Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca2+ while binding to PIP2 is Ca2+ insensitive.
Gene Name: | Synaptotagmin-Like 2 |
Synonyms: | SYTL2, CHR11SYT, EXO4, Exophilin-4, KIAA1597, SGA72M, SLP2, Synaptotagmin-like protein 2, Synaptotagmin-like 2, SLP2A, Chromosome 11 synaptotagmin |
Target Sequences: | NM_032943 NP_116561.1 Q9HCH5 |
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